New insights into BMP9 signaling in liver diseases

被引：8

作者：

Jiang, Qian-Qian ^{[1
]}

Liu, Bei-Bei ^{[2
]}

Xu, Ke-Shu ^{[1
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Gastroenterol, Wuhan 430022, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Ultrasound, Wuhan 430022, Peoples R China

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2021年 / 476卷 / 10期

基金：

中国国家自然科学基金;

关键词：

Bone morphogenetic protein 9 (BMP9); Nonalcoholic fatty liver disease (NAFLD); Liver fibrosis; Hepatocellular carcinoma (HCC); Signaling pathway; BONE MORPHOGENETIC PROTEIN-9; BMP9-INDUCED OSTEOGENIC DIFFERENTIATION; NONALCOHOLIC FATTY LIVER; KINASE; FIBROSIS; INSULIN; CELLS; STEATOHEPATITIS; PATHOGENESIS; IDENTIFICATION;

D O I：

10.1007/s11010-021-04182-6

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Bone morphogenetic protein 9 (BMP9) is a recently discovered cytokine mainly secreted by the liver and is a member of the transforming growth factor beta (TGF-beta) superfamily. In recent years, an increasing number of studies have shown that BMP9 is associated with liver diseases, including nonalcoholic fatty liver disease (NAFLD), liver fibrosis and hepatocellular carcinoma (HCC), and BMP9 signaling may play dual roles in liver diseases. In this review, we mainly summarized and discussed the roles and potential mechanisms of BMP9 signaling in NAFLD, liver fibrosis and HCC. Specifically, this article will provide a better understanding of BMP9 signaling and new clues for the treatment of liver diseases.

引用

页码：3591 / 3600

页数：10

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