Plasma levels of inflammatory and thrombotic/fibrinolytic markers in acute ischemic strokes: Relationship with TOAST subtype, outcome and infarct site

被引：74
|
作者：
Tuttolomondo, Antonino [1 ]
Di Sciacca, Riccardo [1 ]
Di Raimondo, Domenico [1 ]
Serio, Antonia [1 ]
D'Aguanno, Gisella [1 ]
La Placa, Sergio [1 ]
Pecoraro, Rosaria [1 ]
Arnao, Valentina [2 ]
Marino, Luciana [1 ]
Monaco, Serena [3 ,4 ]
Natale, Eraldo [3 ,4 ]
Licata, Giuseppe [1 ]
Pinto, Antonio [1 ]
机构：
[1] Univ Palermo, Dipartimento Biomed Med Interna & Specialist, I-90127 Palermo, Italy
[2] Univ Palermo, Dipartimento Neurosci Clin, I-90127 Palermo, Italy
[3] Azienda Osped Civ Palermo, Div Neurol, I-90127 Palermo, Italy
[4] Azienda Osped Civ Palermo, Stroke Unit, I-90127 Palermo, Italy
来源：
JOURNAL OF NEUROIMMUNOLOGY | 2009年 / 215卷 / 1-2期
关键词：
Cerebral infarct; Cerebrovascular accident; Cerebrovascular disease; Inflammation; Risk factors; Stroke; Cytokines; NECROSIS-FACTOR-ALPHA; PROINFLAMMATORY CYTOKINES; CEREBRAL-ISCHEMIA; ATRIAL-FIBRILLATION; ARTERY OCCLUSION; CAROTID-ARTERY; BRAIN-DAMAGE; PATHOGENESIS; EXPRESSION; SEVERITY;
D O I：
10.1016/j.jneuroim.2009.06.019
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Background: The aim of our study was to evaluate in patients with acute ischemic stroke the relationship between immuno-inflammatory variables, clinical outcome and infarct site. Materials and methods: We evaluated plasma levels of IL-1 beta, TNF-alpha, IL-6 and IL-10, E-selectin, P-selectin, sICAM-1 ,sVCAM-1 vWF, TPA and PAI-1. Results: Patients with cardioembolic subtype showed significantly higher median plasma levels of TNF-alpha, IL-6, IL-1 beta whereas the lacunar subtype showed significantly lower median plasma levels of TNF-alpha, IL-6 and IL-1 beta. Conclusions: A significant association was noted between the severity of neurological deficit at admission, the diagnostic subtype and some inflammatory variables. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码：84 / 89
页数：6
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