A julolidine-chalcone-based fluorescent probe for detection of Al3+ in real water sample and cell imaging

A fluorescent probe 1 based on julolidine-chalcone derivative, which can specifically recognize aluminum ion with high selectivity and anti-interference, was developed. Probe 1 has good fluorescence stability and can detect Al3+ with turn-on fluorescence in a wide pH range of 4.0-9.0. The probe has good repeatability for the detection of Al(3+ )and fluorescence turn-on and off can be repeated with the alternate Al(3+)and EDTA. The sensing mechanism is speculated that Al3+ will coordinate with hydroxyl oxygen and carbonyl oxygen on the probe through in situ 1H NMR and HRMS combing with Job's plot. The probe can also detect Al3+ in actual water samples and applied to monitor Al3+ in biological system. (C) 2022 Elsevier B.V. All rights reserved.