An optimal hydrogen-bond surrogate for α-helices

被引：12
|
作者：
Joy, Stephen T. [1 ]
Arora, Paramjit S. [1 ]
机构：
[1] NYU, Dept Chem, New York, NY 10003 USA
来源：
CHEMICAL COMMUNICATIONS | 2016年 / 52卷 / 33期
基金：
美国国家卫生研究院;
关键词：
IN-VIVO; METATHESIS CATALYSTS; PROTEIN INTERFACES; GLOBULAR-PROTEINS; NUCLEATION; PEPTIDES; MIMETICS; WATER; TRIFLUOROETHANOL; DESIGN;
D O I：
10.1039/c6cc01104g
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Substitution of a main chain i -> i + 4 hydrogen bond with a covalent bond can nucleate and stabilize the alpha-helical conformation in peptides. Herein we describe the potential of different alkene isosteres to mimic intramolecular hydrogen bonds and stabilize alpha-helices in diverse peptide sequences.
引用
收藏
页码：5738 / 5741
页数：4
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