In Vitro Production of Optically Active Octahydrocurcumin by Human Intestinal Bacterium

被引：0

作者：

Niwa, Toshio ^{[1
]}

Yokoyama, Shin-ichiro ^{[2
]}

Mochizuki, Mika ^{[3
]}

Osawa, Toshihiko ^{[3
]}

机构：

[1] Shubun Univ, Fac Hlth & Nutr, 6 Nikkocho, Ichinomiya, Aichi 4910938, Japan

[2] Gifu Prefectural Res Inst Food Sci, 1-1 Yanagito, Gifu 5011112, Japan

[3] Aichi Gakuin Univ, Fac Psychol & Phys Sci, Dept Hlth & Nutr, 12 Araike,Iwasaki Cho, Nisshin, Aichi 4700195, Japan

来源：

BIOLOGICAL & PHARMACEUTICAL BULLETIN | 2022年 / 45卷 / 03期

关键词：

curcumin; hexahydrocurcumin; octahydrocurcumin; metabolism; microflora; KAPPA-B; CURCUMIN; METABOLITES; INHIBIT;

D O I：

暂无

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Enterococcus avium, producing 5R-hexahydrocurcumin metabolized tetrahydrocurcumin to octahydro-curcumin in vitro. Based on a detailed analysis of the two secondary alcohols, the metabolite obtained from tetrahydrocurcumin via 5R-hexahydrocurcumin was identified as 3R,5R-octahydrocurcumin. The activities of 5R-hexahydrocurcumin and 3R,5R-octahydrocurcumin were compared to those of the synthetic com-pounds, using monocyte chemoattractant protein-1 produced via murine adipocytes in vitro. The optically active curcuminoids reduced the cytokine production similar to tetrahydrocurcumin without any difference in their stereochemistry.

引用

页码：378 / 381

页数：4

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