Clinical and pathophysiological significance of anti-neutrophil cytoplasmic autoantibodies in vasculitis syndromes

被引:21
|
作者
Wiik, Allan [1 ]
机构
[1] Statens Serum Inst, Dept Clin Biochem & Immunol, DK-2300 Copenhagen S, Denmark
关键词
ANCA; Vasculitis; Diagnosis; Pathophysiology; INTERNATIONAL CONSENSUS STATEMENT; MONITORING DISEASE-ACTIVITY; WEGENERS-GRANULOMATOSIS; ANTIMYELOPEROXIDASE AUTOANTIBODIES; HUMAN MYELOPEROXIDASE; SYSTEMIC VASCULITIS; ENDOTHELIAL-CELLS; IN-VITRO; ANTIBODIES; ANCA;
D O I
10.1007/s10165-009-0219-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Necrotizing vasculitis of small blood vessels is a rare condition, but when it affects important organs it can lead to life-threatening organ damage and death. Thus, recognizing these conditions at an early stage before they spread to become systemic is a constant challenge to clinical medicine. The objectives of this review are: to give advice on clinical indications for ANCA diagnostics and laboratory procedures for highly specifically detecting the most important ANCA; to provide some data on the autoantigens involved in ANCA reactivity in small vessel vasculitides; and to discuss at the occurrence of ANCA in different vasculitic populations and at different stages of disease. One important task for the near future will be to standardize the assays used for ANCA detection/quantification and to harmonize the results given to clinicians by ensuring that international reference reagents are used by laboratories and the diagnostic industry. Finally, the author has attempted to summarize the role that ANCA are currently believed to play in the immuno-inflammatory events that take place in tissues and that affect small vessels in idiopathic vasculitis. The review concludes that the presence of ANCA is likely to become an important criterion for diagnosing idiopathic small vessel vasculitis.
引用
收藏
页码:590 / 599
页数:10
相关论文
共 50 条
  • [1] Anti-neutrophil cytoplasmic autoantibodies: Methodological aspects and clinical significance in systemic vasculitis
    Radice, Antonella
    Bianchi, Laura
    Sinico, Renato Alberto
    AUTOIMMUNITY REVIEWS, 2013, 12 (04) : 487 - 495
  • [2] Anti-neutrophil Cytoplasmic Autoantibodies Associated Vasculitis Clinical Profile and Outcomes
    Nunna, Kavya Devi
    Devarasetti, Phani Kumar
    Irlapati, Rajendra Vara Prasad
    Rajasekhar, Liza
    INDIAN JOURNAL OF RHEUMATOLOGY, 2018, 13 (02) : 95 - 100
  • [3] Clinical significance of positive anti-neutrophil cytoplasmic antibodies without evidence of anti-neutrophil cytoplasmic antibodies-associated vasculitis
    Bornstein, Gil
    Ben-Zvi, Ilan
    Furie, Nadav
    Grossman, Chagai
    INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES, 2019, 22 (05) : 940 - 945
  • [4] ANTI-NEUTROPHIL CYTOPLASMIC AUTOANTIBODIES
    SPECKS, U
    ROHRBACH, MS
    DEREMEE, RA
    NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (21): : 1416 - 1417
  • [5] Anti-neutrophil cytoplasmic antibodies and their clinical significance
    Supaporn Suwanchote
    Muanpetch Rachayon
    Pongsawat Rodsaward
    Jongkonnee Wongpiyabovorn
    Tawatchai Deekajorndech
    Helen L. Wright
    Steven W. Edwards
    Michael W. Beresford
    Pawinee Rerknimitr
    Direkrit Chiewchengchol
    Clinical Rheumatology, 2018, 37 : 875 - 884
  • [6] Anti-neutrophil cytoplasmic antibodies and their clinical significance
    Suwanchote, Supaporn
    Rachayon, Muanpetch
    Rodsaward, Pongsawat
    Wongpiyabovorn, Jongkonnee
    Deekajorndech, Tawatchai
    Wright, Helen L.
    Edwards, Steven W.
    Beresford, Michael W.
    Rerknimitr, Pawinee
    Chiewchengchol, Direkrit
    CLINICAL RHEUMATOLOGY, 2018, 37 (04) : 875 - 884
  • [7] Anti-neutrophil cytoplasmic autoantibodies in leprosy
    Medina, F
    Camargo, A
    Moreno, J
    Zonana-Nacach, A
    Aceves-Avila, J
    Fraga, A
    BRITISH JOURNAL OF RHEUMATOLOGY, 1998, 37 (03): : 270 - 273
  • [8] ANTI-NEUTROPHIL CYTOPLASMIC AUTOANTIBODIES - REPLY
    JENNETTE, JC
    FALK, RJ
    NEW ENGLAND JOURNAL OF MEDICINE, 1988, 319 (21): : 1417 - 1417
  • [9] Azurocidin is a novel antigen for anti-neutrophil cytoplasmic autoantibodies (ANCA) in systemic vasculitis
    Zhao, MH
    Lockwood, CM
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 1996, 103 (03): : 397 - 402
  • [10] Clinical significance of HEp-2 cell cytoplasmic patterns in anti-neutrophil cytoplasmic antibody associated vasculitis
    Zhang, Naidan
    Ji, Chaixia
    Bao, Xiao
    Yuan, Chengliang
    MEDICINE, 2022, 101 (25)