Regulation of Porcine Endogenous Retrovirus Release by Porcine and Human Tetherins

被引：42
|
作者：
Mattiuzzo, Giada [1 ]
Ivol, Sabrina [1 ]
Takeuchi, Yasuhiro [1 ]
机构：
[1] UCL, Wohl Virion Ctr, Div Infect & Immun, London, England
来源：
JOURNAL OF VIROLOGY | 2010年 / 84卷 / 05期
关键词：
TRANSGENIC PIGS; ENVELOPE GLYCOPROTEIN; PERV TRANSMISSION; HIV-1; VPU; XENOTRANSPLANTATION; CELLS; RESTRICTION; EXPRESSION; PROTEIN; RISK;
D O I：
10.1128/JVI.01928-09
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
The risk of transmission of porcine endogenous retrovirus (PERV) is one of the major safety issues in xenotransplantation. Human tetherin, recently described as an antiviral protein able to inhibit the release of enveloped viruses, and its porcine homologue were shown to inhibit PERV release from producer cells, establishing themselves as candidate molecules to suppress PERV production in porcine xenografts by animal engineering.
引用
收藏
页码：2618 / 2622
页数：5
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