Ru-Catalyzed Decarbonylative Addition of Aliphatic Aldehydes to Terminal Alkynes

被引：48
|
作者：
Guo, Xiangyu [1 ]
Wang, Jun [1 ]
Li, Chao-Jun [1 ]
机构：
[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada
来源：
ORGANIC LETTERS | 2010年 / 12卷 / 14期
基金：
加拿大自然科学与工程研究理事会;
关键词：
CARBOZINCATION;
D O I：
10.1021/ol101107w
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A novel method for the formation of isolated C=C bonds was developed via a ruthenium-catalyzed decarbonylative addition of aliphatic aldehydes and alkynes. An unprecedented complete switch of chemoselectivity from aromatic aldehydes to aliphatic aldehydes was observed simply by using tri(2,4,6-trismethoxyphenyl)phosphine as ligand. A synthesis by this method of an insect sex pheromone was demonstrated.
引用
收藏
页码：3176 / 3178
页数：3
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