Generation of ultra-treatment-resistant schizophrenia patient-derived induced pluripotent stem cell line UJS']JSi002-A

被引：2
|
作者：
Sun, Jing [1 ]
Zeng, Rongsen [1 ]
Liu, Yunxi [1 ]
Xi, Siyu [1 ]
Sun, Tingkai [1 ]
Qian, Jinjun [3 ]
Yi, Zhenghui [4 ]
Qin, Shengying [2 ]
机构：
[1] Jiangsu Univ, Sch Pharm, Neurobiol & Mitochondrial Key Lab, Zhenjiang 212013, Jiangsu, Peoples R China
[2] Shanghai Jiao Tong Univ, Bio X Inst, Key Lab Genet Dev & Neuropsychiat Disorders, Minist Educ, Shanghai 200030, Peoples R China
[3] Fourth Peoples Hosp Zhenjiang, Dept Neurol, Zhenjiang 212013, Jiangsu, Peoples R China
[4] Shanghai Jiao Tong Univ, Shanghai Mental Hlth Ctr, Shanghai Key Lab Psychot Disorders, Sch Med, Shanghai 201100, Peoples R China
来源：
STEM CELL RESEARCH | 2022年 / 61卷
基金：
中国博士后科学基金;
关键词：
D O I：
10.1016/j.scr.2022.102766
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Schizophrenia is a chronic, serious and disabling mental disorder. Most patients can effectively control their condition through drug treatment, but there are still some patients who are difficult to gain benefits from drug treatment. Among them, the failure to respond to clozapine full-scale treatment is ultra-treatment-resistant schizophrenia. We generated induced pluripotent stem cells (iPSCs) from an ultra-treatment-resistant schizophrenia patient by electroporation of peripheral blood mononuclear cells (PBMCs) with episomal plasmids encoding OCT 4, SOX 2, NANOG, LIN 28, KLF 4 and MYC. The iPSCs demonstrated normal karyotype, expressed pluripotency markers and differentiated into the three germ layers in vivo.
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页数：4
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