Induction of BRCAness in Triple-Negative Breast Cancer by a CDK12/13 Inhibitor Improves Chemotherapy

被引：17
|
作者：
Hopkins, Jessica L. [1 ]
Zou, Lee [1 ,2 ]
机构：
[1] Harvard Med Sch, Massachusetts Gen Hosp, Canc Ctr, Charlestown, MA 02129 USA
[2] Harvard Med Sch, Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA
来源：
CANCER CELL | 2019年 / 36卷 / 05期
关键词：
D O I：
10.1016/j.ccell.2019.10.012
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
In this issue of Cancer Cell, Quereda and colleagues report that a newly developed specific inhibitor of CDK12/13, SR-4835, sensitizes triple-negative breast cancer cells to PARP inhibitors and DNA-damaging chemotherapeutics by reducing expression of the genes in the DNA damage response pathway.
引用
收藏
页码：461 / 463
页数：4
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