Association of risk of abnormal bleeding with degree of serotonin reuptake inhibition by antidepressants

被引:185
|
作者
Meijer, WEE
Heerdink, ER
Nolen, WA
Herings, RMC
Leufkens, HGM
Egberts, ACG
机构
[1] Utrecht Inst Pharmaceut Sci, Dept Pharmacoepidemiol & Pharmacotherapy, NL-3508 TB Utrecht, Netherlands
[2] Kendle Int, NL-3508 TB Utrecht, Netherlands
[3] Univ Groningen Hosp, Dept Psychiat, Groningen, Netherlands
[4] PHARMO Inst Drug Outcome Res, Utrecht, Netherlands
[5] TweeSteden & St Elisabeth Hosp, Hosp Pharm Midden Brabant, Tilburg, Netherlands
关键词
D O I
10.1001/archinte.164.21.2367
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Serotonin plays a role in platelet aggregation. Because antidepressants influence blood serotonin levels, their use may be associated with an increased risk of abnormal bleeding. However, previous studies were inconclusive regarding this association. The aim of this study was to estimate the risk of abnormal bleeding associated with the use of antidepressants and to establish the relationship between serotonin reuptake inhibition and the risk of bleeding. Methods: We used data collected from 1992 through 2000 to conduct a nested case-control study of a cohort of more than 64 000 new antidepressant users. Cases were identified as all patients hospitalized for a primary diagnosis of abnormal bleeding, and they were matched with controls for age and sex. We classified exposure according to the degree (high, intermediate, or low) of serotonin reuptake inhibition and performed logistic regression analysis to calculate odds ratios. Results: There were 196 cases of abnormal bleeding. The risk of hospitalization increased with the use of inhibitors providing intermediate (odds ratio, 1.9; 95% confidence interval, 1.1-3.5) and high degrees of serotonin reuptake inhibition (odds ratio, 2.6; 95% confidence interval, 1.4-4.8). Conclusions: In a large population of new antidepressant users we found a significant association between degree of serotonin reuptake inhibition by antidepressants and risk of hospital admission for abnormal bleeding as the primary diagnosis. An increased risk of abnormal bleeding was strongly associated with the degree of serotonin reuptake inhibition.
引用
收藏
页码:2367 / 2370
页数:4
相关论文
共 50 条
  • [1] DEGREE OF SEROTONIN REUPTAKE INHIBITION OF ANTIDEPRESSANTS AND RISK OF ISCHEMIC STROKE
    Douros, A.
    Dell'Aniello, S.
    Dehghan, G.
    Boivin, J. F.
    Renoux, C.
    INTERNATIONAL JOURNAL OF STROKE, 2018, 13 : 33 - 33
  • [2] Risk of upper gastrointestinal bleeding and the degree of serotonin Reuptake inhibition by antidepressants -: A case-control study
    Vidal, Xavier
    Ibanez, Luisa
    Vendrell, Lourdes
    Conforti, Ana
    Laporte, Joan-Ramon
    DRUG SAFETY, 2008, 31 (02) : 159 - 168
  • [3] Degree of serotonin reuptake inhibition of antidepressants and ischemic risk A cohort study
    Douros, Antonios
    Dell'Aniello, Sophie
    Dehghan, Golsa
    Boivin, Jean-Francois
    Renoux, Christel
    NEUROLOGY, 2019, 93 (10) : E1010 - E1020
  • [4] Degree of serotonin reuptake inhibition of antidepressants and the risk of ischemic stroke and myocardial infarction
    Douros, Antonios
    Dell'Aniello, Sophie
    Dehghan, Golsa
    Boivin, Jean-Francois
    Renoux, Christel
    PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 2018, 27 : 21 - 21
  • [5] Serotonin Reuptake Inhibitors and Risk of Abnormal Bleeding
    Andrade, Chittaranjan
    Sharma, Eesha
    PSYCHIATRIC CLINICS OF NORTH AMERICA, 2016, 39 (03) : 413 - +
  • [7] Selective serotonin reuptake inhibitors and abnormal bleeding: Is there an association?
    Chang, A
    Harper, GM
    Covinsky, KE
    JOURNAL OF GENERAL INTERNAL MEDICINE, 2005, 20 : 262 - 262
  • [9] Author response: Degree of serotonin reuptake inhibition of antidepressants and ischemic risk: A cohort study
    Douros, Antonios
    Boivin, Jean-Francois
    Renoux, Christel
    NEUROLOGY, 2020, 95 (05) : 232 - 232
  • [10] Serotonin Reuptake Inhibitor Antidepressants and Abnormal Bleeding: A Review for Clinicians and a Reconsideration of Mechanisms
    Andrade, Chittaranjan
    Sandarsh, Surya
    Chethan, Kumar B.
    Nagesh, Koregala S.
    JOURNAL OF CLINICAL PSYCHIATRY, 2010, 71 (12) : 1565 - 1575