JMJD3 in the regulation of human diseases

被引：84
|
作者：
Zhang, Xiangxian [1 ]
Liu, Li [1 ]
Yuan, Xia [1 ]
Wei, Yuquan [1 ]
Wei, Xiawei [1 ]
机构：
[1] Sichuan Univ, West China Hosp, Natl Clin Res Ctr Geriatr, Lab Aging Res & Nanotoxicol,State Key Lab Biother, Chengdu 610041, Sichuan, Peoples R China
来源：
PROTEIN & CELL | 2019年 / 10卷 / 12期
基金：
中国国家自然科学基金;
关键词：
histone methylation; JMJD3; epigenetics; human diseases; NF-KAPPA-B; HISTONE DEMETHYLASE JMJD3; GENOME-WIDE ANALYSIS; GENE-EXPRESSION; EPIGENETIC REGULATION; H3K27ME3; DEMETHYLASE; MACROPHAGE POLARIZATION; INFLAMMATORY GENES; INK4A-ARF LOCUS; VITAMIN-D;
D O I：
10.1007/s13238-019-0653-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In recent years, many studies have shown that histone methylation plays an important role in maintaining the active and silent state of gene expression in human diseases. The Jumonji domain-containing protein D3 (JMJD3), specifically demethylate di- and trimethyl-lysine 27 on histone H3 (H3K27me2/3), has been widely studied in immune diseases, infectious diseases, cancer, developmental diseases, and aging related diseases. We will focus on the recent advances of JMJD3 function in human diseases, and looks ahead to the future of JMJD3 gene research in this review.
引用
收藏
页码：864 / 882
页数：19
相关论文
共 50 条
  • [1] JMJD3 in the regulation of human diseases
    Xiangxian Zhang
    Li Liu
    Xia Yuan
    Yuquan Wei
    Xiawei Wei
    Protein & Cell, 2019, 10 (12) : 864 - 882
  • [2] Emerging roles of JMJD3 in cancer
    Farzaneh, Maryam
    Kuchaki, Zeinab
    Rashid Sheykhahmad, Fatima
    Meybodi, Seyed Mohammadmahdi
    Abbasi, Yusef
    Gholami, Effat
    Ghaedrahmati, Farhoodeh
    Anbiayee, Omid
    CLINICAL & TRANSLATIONAL ONCOLOGY, 2022, 24 (07): : 1238 - 1249
  • [3] The Functions of the Demethylase JMJD3 in Cancer
    Sanchez, Anna
    Houfaf Khoufaf, Fatma Zohra
    Idrissou, Mouhamed
    Penault-Llorca, Frederique
    Bignon, Yves-Jean
    Guy, Laurent
    Bernard-Gallon, Dominique
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (02) : 1 - 18
  • [4] Emerging roles of JMJD3 in cancer
    Maryam Farzaneh
    Zeinab Kuchaki
    Fatima Rashid Sheykhahmad
    Seyed Mohammadmahdi Meybodi
    Yusef Abbasi
    Effat Gholami
    Farhoodeh Ghaedrahmati
    Omid Anbiyaee
    Clinical and Translational Oncology, 2022, 24 : 1238 - 1249
  • [5] In Silico Identification of JMJD3 Demethylase Inhibitors
    Esposito, C.
    Wiedmer, L.
    Caflisch, A.
    JOURNAL OF CHEMICAL INFORMATION AND MODELING, 2018, 58 (10) : 2151 - 2163
  • [6] JMJD3 as an epigenetic regulator in development and disease
    Burchfield, Jana S.
    Li, Qingtian
    Wang, Helen Y.
    Wang, Rong-Fu
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2015, 67 : 148 - 157
  • [7] Role of H3K27 Demethylases Jmjd3 and UTX in Transcriptional Regulation
    Hubner, M. R.
    Spector, D. L.
    NUCLEAR ORGANIZATION AND FUNCTION, 2010, 75 : 43 - 49
  • [8] The Role of JMJD3 in Ovarian Follicular Development
    Roy, Shyamal K.
    ENDOCRINOLOGY, 2022, 163 (07)
  • [9] Correction to: Emerging roles of JMJD3 in cancer
    Maryam Farzaneh
    Zeinab Kuchaki
    Fatima Rashid Sheykhahmad
    Seyed Mohammadmahdi Meybodi
    Yusef Abbasi
    Effat Gholami
    Farhoodeh Ghaedrahmati
    Omid Anbiyaee
    Clinical and Translational Oncology, 2022, 24 (10) : 2044 - 2044
  • [10] Critical Role of Histone Demethylase JMJD3 in the Regulation of Macrophage Polarization and Renal Fibrosis
    An, Changlong
    Jiao, Baihai
    Wang, Yanlin
    JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2021, 32 (10): : 755 - 755
12345