Studies of the total synthesis of epothilone B and D: A facile synthesis of C7-C14 and C15-C21 fragments

被引：0
|
作者：
Zhang, HS [1 ]
Zhong, CF [1 ]
Bao, XP [1 ]
机构：
[1] Hubei Univ, Dept Chem, Wuhan 430062, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2003年 / 14卷 / 02期
关键词：
epothilone B and D; anticancer drugs; nerol; synthesis;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A mild and highly efficient synthesis of C7-C14 and C15-C21 fragments of epothilone 13 and D is described in which racemic C7-C14 fragment is prepared from nerol through lour steps, and C15-C21 fragment is obtained from 1,3-dichloroacetone, thioacetamide and propionaldehyde.
引用
收藏
页码：115 / 117
页数：3
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