New benzophenone phosphonate derivatives

被引：3
|
作者：
Gaman, Maxim S. [1 ]
Matyugina, Elena S. [1 ]
Novikov, Mikhail S. [2 ]
Babkov, Denis A. [2 ]
Solyev, Pavel N. [1 ]
Kochetkov, Sergey N. [1 ]
Khandazhinskaya, Anastasia L. [1 ]
机构：
[1] Russian Acad Sci, VA Engelhardt Mol Biol Inst, Moscow 119991, Russia
[2] Volgograd State Med Univ, Volgograd 400131, Russia
来源：
MENDELEEV COMMUNICATIONS | 2017年 / 27卷 / 04期
基金：
俄罗斯科学基金会; 俄罗斯基础研究基金会;
关键词：
REVERSE-TRANSCRIPTASE INHIBITORS; POTENT;
D O I：
10.1016/j.mencom.2017.07.008
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New well-soluble in 10% DMSO phosphonate derivatives of substituted benzophenone have been synthesized using different methods. Preliminary computer modeling of proposed structures in the reverse transcriptase HIV-1 hydrophobic pocket suggested these molecules as potential non-nucleoside inhibitors of this enzyme.
引用
收藏
页码：346 / 348
页数：3
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