Solid-phase synthesis of 5-aminotetrazoles

被引：34
|
作者：
Yu, YP
Ostresh, JM
Houghten, RA
机构：
[1] Torrey Pines Inst Mol Studies, San Diego, CA 92121 USA
[2] Zhejiang Univ, Coll Pharmaceut Sci, Hangzhou 310031, Zhejiang, Peoples R China
来源：
TETRAHEDRON LETTERS | 2004年 / 45卷 / 41期
关键词：
D O I：
10.1016/j.tetlet.2004.07.160
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A solid-phase synthesis of 5-aminotetrazoles is described. Resin-bound thioureas were displaced by sodium azide in the presence of HgCl2 and following nucleophilic cyclization produced the resin-bound products. The desired 5-aminotetrazoles were cleaved from the resin using 95% trifluoroacetic acid in dichloromethane in good yield and purity. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码：7787 / 7789
页数：3
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