Impaired recognition memory and decreased prefrontal cortex spine density in aged female rats

被引：45
|
作者：
Wallace, Maureen
Frankfurt, Maya
Arellanos, Adolfo
Inagaki, Tomoko
Luine, Victoria
机构：
[1] CUNY Hunter Coll, Dept Psychol, New York, NY 10021 USA
[2] CUNY, Sch Med, Dept Physiol Pharmacol, New York, NY 10031 USA
来源：
IMAGING AND THE AGING BRAIN | 2007年 / 1097卷
关键词：
aging; memory; golgi; dendritic spine density; prefrontal cortex;
D O I：
10.1196/annals.1379.026
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Aged F344 female rats (21 months) showed decreased performance, as compared to young rats (4 months), on an object recognition memory task. Golgi impregnation measured dendritic spine density of pyramidal neurons in the prefrontal cortex (layer II-III), a brain area important for recognition memory. Densities of spines in aged rats were 16% lower in tertiary, apical dendrites, but not significantly different in secondary basal dendrites. Concurrent measures of memory and spine density in the young and aged subjects show that age-related declines in recognition memory are associated with decreased cortical spine density.
引用
收藏
页码：54 / 57
页数：4
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