Highly Efficient One-Pot Synthesis of 2-Substituted Quinazolines and 4H-Benzo[d][1,3]oxazines via Cross Dehydrogenative Coupling using Sodium Hypochlorite

被引：125

作者：

Maheswari, C. Uma ^{[1
]}

Kumar, G. Sathish ^{[1
]}

Venkateshwar, M. ^{[1
]}

Kumar, R. Arun ^{[1
]}

Kantam, M. Lakshmi ^{[1
]}

Reddy, K. Rajender ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Inorgan & Phys Chem Div, Hyderabad 500607, Andhra Pradesh, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 2-3期

关键词：

2-aryl-4H-benzo[d][1,3]oxazines; dehydrogenation; oxidation; quinazolines; sodium hypochlorite; TYROSINE KINASE INHIBITORS; DERIVATIVES; RECEPTOR; ALDEHYDES; AMINES; 4-ANILINOQUINAZOLINES; 2-ARYLBENZOXAZOLES; DISCOVERY; OXIDATION; QUINOLINE;

D O I：

10.1002/adsc.200900715

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This communication describes a catalyst-free synthesis of 2-substituted quinazolines and 4H-benzo[d][1,3]oxazines using commericially available sodium hypochlorite as oxidant. Operational simplicity, mild reaction conditions and the ability to construct structurally diverse 2-quinazolines and 2-substituted 4H-benzo[d][1,3]oxazines by this method render it to be a practical alternative for the synthesis of these heterocycles.

引用

页码：341 / 346

页数：6

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