DDX3X: stressing the NLRP3 inflammasome

被引：15

作者：

Fox, Daniel ^{[1
]}

Man, Si Ming ^{[1
]}

机构：

[1] Australian Natl Univ, John Curtin Sch Med Res, Dept Immunol & Infect Dis, Canberra, ACT 2601, Australia

来源：

CELL RESEARCH | 2019年 / 29卷 / 12期

基金：

英国医学研究理事会;

关键词：

NEK7; ACTIVATION;

D O I：

10.1038/s41422-019-0250-8

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stress granules and inflammasomes are intracellular complexes that assemble in response to cellular stress signals, enabling cells to persist and perish, respectively. In a recent study published in Nature, Samir et al. identify the helicase DDX3X as a central decision maker in the formation of prosurvival stress granules or pro-death NLRP3 inflammasomes.

引用

页码：969 / 970

页数：2

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