Separation and recognition of the enantiomers of trans arylcyclopropanecarboxylic acids and their amide and nitrile derivatives on polysaccharide stationary phases

Separation of the enantiomers of several trans arylcyclopropanecarboxylic acids and their amide and nitrile derivatives has been systematically studied on three polysaccharide HPLC stationary phases, amylose tris-(3,5-dimethylphenylcarbamate), cellulose tris-(3,5-dimethylphenylcarbamate), and cellulose tris-(4-methylbenzoate). Enantiomer recognition by the chiral stationary phases is discussed in terms of the type of functional group, electronic and steric effects of substituents, on the analytes, the structure of the chiral stationary phase, and mobile phase composition.