Polymeric nucleic acid delivery for immunoengineering

被引：18

作者：

Tzeng, Stephany Y. ^{[1
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Green, Jordan J. ^{[1
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机构：

[1] Johns Hopkins Univ, Dept Biomed Engn, Sch Med, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Translat Tissue Engn Ctr, Sch Med, Baltimore, MD 21231 USA

[3] Johns Hopkins Univ, Inst Nanobiotechnol, Baltimore, MD 21218 USA

[4] Johns Hopkins Univ, Dept Mat Sci & Engn, Baltimore, MD 21218 USA

[5] Johns Hopkins Univ, Dept Chem, Charles & 34Th St, Baltimore, MD 21218 USA

[6] Johns Hopkins Univ, Dept Biomol Engn, Baltimore, MD 21218 USA

[7] Johns Hopkins Univ, Sch Med, Dept Oncol, Baltimore, MD 21231 USA

[8] Johns Hopkins Univ, Sch Med, Dept Ophthalmol, Baltimore, MD 21231 USA

[9] Johns Hopkins Univ, Sch Med, Dept Neurosurg, Baltimore, MD 21231 USA

[10] Johns Hopkins Univ, Sch Med, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD 21231 USA

来源：

CURRENT OPINION IN BIOMEDICAL ENGINEERING | 2018年 / 7卷

关键词：

Immunoengineering; Gene delivery; Vaccines; Immunotherapy; Polymers; CANCER-IMMUNOTHERAPY; CPG OLIGONUCLEOTIDES; CONTROLLED-RELEASE; DENDRITIC CELLS; IMMUNE-RESPONSE; GENE; DNA; NANOPARTICLES; SIRNA; POLYETHYLENIMINE;

D O I：

10.1016/j.cobme.2018.09.005

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

Nucleic acids hold promise as tools for engineering the immune system. However, for use in patients, their delivery must be improved to overcome challenges in specificity and intracellular delivery efficiency. Polymers, both natural and synthetic, are under investigation as nucleic acid delivery vehicles, and their chemical and physical properties are being engineered to enhance their efficacy. Through formulation with polymers, DNA, mRNA, siRNA, and other nucleic acids can serve as prophylactic or therapeutic vaccines by over-expressing or knocking down expression of genes that affect the immune response. Polymeric delivery is also useful for the transport of intrinsically immunostimulatory nucleic acids to specific compartments of cells. Recent innovative examples of polymer-based nucleic acid vaccines and immunomodulatory strategies will be discussed.

引用

页码：42 / 50

页数：9

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