The effects of exposure to titanium dioxide nanoparticles during lactation period on learning and memory of rat offspring

被引：42
|
作者：
Mohammadipour, Abbas [1 ]
Hosseini, Mahmoud [2 ]
Fazel, Alireza [1 ]
Haghir, Hossein [1 ]
Rafatpanah, Houshang [3 ]
Pourganji, Masoume [4 ]
Bideskan, Alireza Ebrahimzadeh [1 ]
机构：
[1] Mashhad Univ Med Sci, Sch Med, Dept Anat, Mashhad 9177948564, Iran
[2] Mashhad Univ Med Sci, Sch Med, Dept Physiol, Neurocognit Res Ctr, Mashhad 9177948564, Iran
[3] Mashhad Univ Med Sci, Buali Inst, Immunol Res Ctr, Mashhad 9177948564, Iran
[4] Mashhad Univ Med Sci, Sch Med, Appl Physiol Res Ctr, Mashhad 9177948564, Iran
来源：
TOXICOLOGY AND INDUSTRIAL HEALTH | 2016年 / 32卷 / 02期
关键词：
Titanium dioxide nanoparticles; maternal; memory and learning; rat; Morris water maze; passive avoidance; WATER MAZE TASKS; CYTOTOXICITY; RESPONSES; TOXICITY; LESION; MICE;
D O I：
10.1177/0748233713498440
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
Nanoscale titanium dioxide (TiO2), which is massively produced and widely used in living environment, seems to have a potential risk on human health. The central nervous system (CNS) is the potential susceptible target of nanoparticles, but the studies on this aspect are limited so far. The aim of this study was to evaluate the effects of exposure to TiO2 nanoparticles during lactation period on learning and memory of offspring. Lactating Wistar rats were exposed to TiO2 nanoparticles (100 mg/kg; gavage) for 21 days. The Morris water maze and passive avoidance tests showed that the exposure to TiO2 nanoparticles could significantly impair the memory and learning in the offspring. Therefore, the application of TiO2 nanoparticles and the effects of their exposure, especially during developmental period on human brain should be cautious.
引用
收藏
页码：221 / 228
页数：8
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