Analytical Methods for the Determination of Chlorhexidine: A Review

被引：21

作者：

Masquio Fiorentino, Flavia Angelica ^{[1
]}

Correa, Marcos Antonio ^{[2
]}

Nunes Salgado, Herida Regina ^{[1
,2
]}

机构：

[1] UNESP, Fac Ciencias Farmaceut Araraquara, Programa Posgrad Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil

[2] UNESP, Fac Ciencias Farmaceut Araraquara, Dept Farmacos & Medicamentos, BR-14801902 Araraquara, SP, Brazil

来源：

CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY | 2010年 / 40卷 / 02期

关键词：

review; chlorhexidine; methods of analysis; LIQUID-CHROMATOGRAPHIC METHOD; DEGRADATION-PRODUCTS; P-CHLOROANILINE; HPLC DETERMINATION; HUMAN-SERUM; DIGLUCONATE; ASSAY; SALIVA; RELEASE; 4-CHLOROANILINE;

D O I：

10.1080/10408340903232020

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Chlorhexidine is a type of antiseptic belonging to biguanidic group and it is large, used in dentistry, human, and veterinary medicine because it is active against Gram-positive and Gram-negative microorganisms. It can be incorporated in several types of preparations and for this reason are necessary effective analytical procedures for quality control and pharmacodynamic and pharmacokinetic studies. Chlorhexidine can be analyzed by many types of assays, however the HPLC is the most used method. In this review, various methods to analyze chlorhexidine including spectrometry, chromatography, colorimetric reaction, solid phase extraction, and capillary electrophoresis are presented and the application of these methods for the determination of chlorhexidine in biological fluids and formulations are discussed.

引用

页码：89 / 101

页数：13

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