USING A MOLECULAR SENSOR ARRAY WITH COLORIMETRIC DETECTION TO IDENTIFY ACTIVE INGREDIENTS IN DRUG FORMULATIONS

被引：2
|
作者：
Chaplenko, A. A. [1 ]
Monogarova, O. V. [1 ]
Oskolok, K. V. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Dept Chem, 1-3 Leninskie Gory, Moscow 119991, Russia
来源：
PHARMACEUTICAL CHEMISTRY JOURNAL | 2019年 / 53卷 / 04期
关键词：
molecular sensor; digital colorimetry; active ingredient; medicine; drug substance; QUALITY-CONTROL; COLOR; ASSAY;
D O I：
10.1007/s11094-019-02004-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A method for multiplex digital colorimetric qualitative analysis of nonsteroidal anti-inflammatory drugs (meloxicam, acetylsalicylic acid and its metabolites, paracetamol), beta-adrenoblockers (carvedilol), secretolytics (bromhexine), fluoroquinolones (ofloxacin), metabolic stimulants (meldonium dihydrate), etc., was developed. The molecular chip operating efficiency was confirmed by verifying the authenticity of >40 medicinal substances. The proposed universal approach was new in principle and could be used for pharmaceutical quality control.
引用
收藏
页码：347 / 352
页数：6
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