Amperometric In Vitro Monitoring of Penetration through Skin Membrane

被引：5

作者：

Gari, Hala ^{[1
]}

Rembiesa, Jadwiga ^{[1
]}

Masilionis, Ignas ^{[1
]}

Vreva, Naida ^{[1
]}

Svensson, Birgitta ^{[2
]}

Sund, Torbjorn ^{[2
]}

Hansson, Henri ^{[3
]}

Moren, Anna Karin ^{[3
]}

Sjoo, Malin ^{[4
]}

Wahlgren, Marie ^{[5
]}

Engblom, Johan ^{[1
]}

Ruzgas, Tautgirdas ^{[1
]}

机构：

[1] Malmo Univ, Fac Hlth & Soc, Dept Biomed Sci, S-20506 Malmo, Sweden

[2] Bioglan AB, S-20213 Malmo, Sweden

[3] Galenica AB, S-20512 Malmo, Sweden

[4] Speximo AB, S-22381 Lund, Sweden

[5] Lund Univ, Ctr Chem, LTH, Div Food Technol, S-22100 Lund, Sweden

来源：

ELECTROANALYSIS | 2015年 / 27卷 / 01期

基金：

瑞典研究理事会;

关键词：

Penetration; Transdermal delivery; Amperometry; Quercetin; Hydrogen peroxide; Ascorbic acid; Skin membrane; TRANSDERMAL DRUG-DELIVERY; REAL-TIME; OXIDATIVE STRESS; HEAT-SEPARATION; ASCORBIC-ACID; DAMAGED SKIN; ELECTRODES; QUERCETIN; PERMEATION; ABSORPTION;

D O I：

10.1002/elan.201400426

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The aim of this study was to demonstrate that penetration of quercetin, hydrogen peroxide and ascorbic acid through skin membranes can be monitored amperometrically. Skin membrane was fixed on the top of chemically modified electrodes and penetration of the appropriate compound was registered as electrode current. The methodology allows the study of penetration from solution as well as from pharmaceutical creams. From real-time measurements of electrode current, fluxes and diffusion coefficients of mentioned compounds in skin membranes have been estimated.

引用

页码：111 / 117

页数：7

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