A pH-Sensitive Fusogenic Peptide Facilitates Endosomal Escape and Greatly Enhanced the Gene Silencing of siRNA-Containing Nanoparticles In Vitro and In Vivo

被引:0
|
作者
Hatakeyama, Hiroto [1 ,3 ]
Itho, Erika [1 ,3 ]
Akita, Hidetaka [1 ,3 ]
Oihi, Motoi [2 ,3 ]
Nagasaki, Yukio [2 ,3 ]
Futaki, Shiroh [4 ]
Harashima, Hideyoshi [1 ,3 ]
机构
[1] Hokkaido Univ, Fac Pharmaceut Sci, Sapporo, Hokkaido 060, Japan
[2] Univ Tsukuba, TIMS, Tsukuba, Ibaraki, Japan
[3] JST, CREST, Saitama, Japan
[4] Kyoto Univ, Chem Res Inst, Uji, Kyoto, Japan
关键词
D O I
暂无
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:S388 / S388
页数:1
相关论文
共 14 条
  • [1] A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
    Hatakeyama, Hiroto
    Ito, Erika
    Akita, Hidetaka
    Oishi, Motoi
    Nagasaki, Yukio
    Futaki, Shiroh
    Harashima, Hideyoshi
    JOURNAL OF CONTROLLED RELEASE, 2009, 139 (02) : 127 - 132
  • [2] A pH-sensitive cationic lipid facilitates the delivery of liposomal siRNA and gene silencing activity in vitro and in vivo
    Sato, Yusuke
    Hatakeyama, Hiroto
    Sakurai, Yu
    Hyodo, Mamoru
    Akita, Hidetaka
    Harashima, Hideyoshi
    JOURNAL OF CONTROLLED RELEASE, 2012, 163 (03) : 267 - 276
  • [3] A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway
    Yuya Nishimura
    Koichi Takeda
    Ryosuke Ezawa
    Jun Ishii
    Chiaki Ogino
    Akihiko Kondo
    Journal of Nanobiotechnology, 12
  • [4] A display of pH-sensitive fusogenic GALA peptide facilitates endosomal escape from a Bio-nanocapsule via an endocytic uptake pathway
    Nishimura, Yuya
    Takeda, Koichi
    Ezawa, Ryosuke
    Ishii, Jun
    Ogino, Chiaki
    Kondo, Akihiko
    JOURNAL OF NANOBIOTECHNOLOGY, 2014, 12
  • [5] An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
    Sasaki, Kentaro
    Kogure, Kentaro
    Chaki, Shinji
    Nakamura, Yoshio
    Moriguchi, Rumiko
    Hamada, Hirofumi
    Danev, Radostin
    Nagayama, Kuniaki
    Futaki, Shiroh
    Harashima, Hideyoshi
    ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (08) : 2717 - 2727
  • [6] An artificial virus-like nano carrier system: enhanced endosomal escape of nanoparticles via synergistic action of pH-sensitive fusogenic peptide derivatives
    Kentaro Sasaki
    Kentaro Kogure
    Shinji Chaki
    Yoshio Nakamura
    Rumiko Moriguchi
    Hirofumi Hamada
    Radostin Danev
    Kuniaki Nagayama
    Shiroh Futaki
    Hideyoshi Harashima
    Analytical and Bioanalytical Chemistry, 2008, 391 : 2717 - 2727
  • [7] Defined pH-sensitive nanogels as gene delivery platform for siRNA mediated in vitro gene silencing
    Dimde, Mathias
    Neumann, Falko
    Reisbeck, Felix
    Ehrmann, Svenja
    Cuellar-Camacho, Jose Luis
    Steinhilber, Dirk
    Ma, Nan
    Haag, Rainer
    BIOMATERIALS SCIENCE, 2017, 5 (11) : 2328 - 2336
  • [8] Delivery of siRNA to the Target Cell Cytoplasm: Photochemical Internalization Facilitates Endosomal Escape and Improves Silencing Efficiency, In Vitro and In Vivo
    Oliveira, S.
    Hogset, A.
    Storm, G.
    Schiffelers, M.
    CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (34) : 3686 - 3697
  • [9] The use of pH-sensitive functional selenium nanoparticles shows enhanced in vivo VEGF-siRNA silencing and fluorescence imaging
    Yu, Qiandian
    Liu, Yanan
    Cao, Chengwen
    Le, Fangling
    Qin, Xiuying
    Sun, Dongdong
    Liu, Jie
    NANOSCALE, 2014, 6 (15) : 9279 - 9292
  • [10] Superb in vitro transfection efficiency and in vivo target gene silencing effects on systemic siRNA delivery by 10-nm scale pH-sensitive ultra-nanoparticles.
    Wu, Xin
    Yamamoto, Hirofumi
    Uemura, Mamoru
    Haraguchi, Naotsugu
    Hata, Taishi
    Nishimura, Junichi
    Takemasa, Ichiro
    Mizushima, Tsunekazu
    Doki, Yuichiro
    Mori, Masaki
    CANCER RESEARCH, 2013, 73 (08)