The cyclophilin inhibitor Debio-025 is a potent inhibitor of hepatitis C virus replication in vitro with a unique resistance profile

被引：7
|
作者：
Coelmont, Lotte
Paeshuyse, Jan
Kaptein, Suzanne
Vliegen, Inge
Kaul, Artur
De Clercq, Erik
Rosenwirth, Brigitte
Scalfaro, Pietro
Crabbe, Raf
Bartenschlager, Ralf
Dumont, Jean-Maurice
Neyts, Johan
机构：
[1] Katholieke Univ Leuven, Rega Inst, Louvain, Belgium
[2] Univ Heidelberg, Heidelberg, Germany
[3] Debiopharm, Lausanne, Switzerland
[4] Med Univ Wien, Vienna, Austria
来源：
ANTIVIRAL RESEARCH | 2007年 / 74卷 / 03期
关键词：
D O I：
10.1016/j.antiviral.2007.01.037
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
29
引用
收藏
页码：A39 / A39
页数：1
相关论文
共 50 条
  • [1] The cyclophilin inhibitor DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    Paeshuyse, Jan
    Coelmont, Lotte
    Kaul, Artur
    Vliegen, Inge
    De Clercq, Erik
    Rosenwirth, Brigitte
    Dumont, Jean-Maurice
    Scalfaro, Pietro
    Bartenschlger, Mf
    Neyts, Johan
    HEPATOLOGY, 2006, 44 (04) : 346A - 346A
  • [2] The non-immunosuppressive cyclosporin DEBIO-025 is a potent inhibitor of hepatitis C virus replication in vitro
    Paeshuyse, J
    Kaul, A
    De Clercq, E
    Rosenwirth, B
    Dumont, JM
    Scalfaro, P
    Bartenschlager, R
    Neyts, J
    HEPATOLOGY, 2006, 43 (04) : 761 - 770
  • [3] DEBIO-025 Cyclophilin Inhibitor Treatment of HCV Infection
    Campas, C.
    Castaner, R.
    DRUGS OF THE FUTURE, 2008, 33 (12) : 1012 - 1017
  • [4] The cyclophilin inhibitor debio-025 shows potent anti-hepatitis C effect in patients coinfected with hepatitis C and human immunodeficiency virus
    Flisiak, Robert
    Horban, Andrzej
    Gallay, Philippe
    Bobardt, Michael
    Selvarajah, Suganya
    Wiercinska-Drapalo, Alicja
    Siwak, Ewa
    Cielniak, Iwona
    Higersberger, Jozef
    Kierkus, Jarek
    Aeschlimann, Christian
    Grosgurin, Pierre
    Nicolas-Metral, Valerie
    Dumont, Jean-Maurice
    Porchet, Herve
    Crabbe, Raf
    Scalfaro, Pietro
    HEPATOLOGY, 2008, 47 (03) : 817 - 826
  • [5] PARTICULAR IN VITRO ANTI-HCV ACTIVITIES AND RESISTANCE PROFILE OF THE CYCLOPHILIN INHIBITOR DEBIO 025
    Coelmont, L.
    Gallay, P.
    Bobardt, M.
    Kaptein, S.
    Paeshuyse, J.
    Vliegen, I.
    Vuagniaux, G.
    Neyts, J.
    JOURNAL OF HEPATOLOGY, 2009, 50 : S36 - S36
  • [6] Potent and selective inhibition of hepatitis C virus replication by the non-immunosuppressive cyclosporin analogue DEBIO-025
    Paeshuyse, J
    Dumont, JM
    Rosenwirth, B
    De Clercq, E
    Neyts, J
    ANTIVIRAL RESEARCH, 2005, 65 (03) : A41 - A41
  • [7] The reduction of both cyclophilin B and HCV-RNA by the cyclophilin inhibitor debio-025 confirms the importance of cyclophilin B for HCV replication in man
    Gallay, R.
    Flisiak, R.
    Horban, A.
    Aeschlimann, C.
    Dumont, J. M.
    Porchet, H.
    Scalfaro, P.
    Crabbe, R.
    JOURNAL OF HEPATOLOGY, 2007, 46 : S296 - S296
  • [8] An evaluation of the cyclophilin inhibitor Debio 025 and its potential as a treatment for chronic hepatitis C
    Crabbe, Raf
    Vuagniaux, Gregoire
    Dumont, Jean-Maurice
    Nicolas-Metral, Valerie
    Marfurt, Judith
    Novaroli, Laura
    EXPERT OPINION ON INVESTIGATIONAL DRUGS, 2009, 18 (02) : 211 - 220
  • [9] Cyclophilin A Inhibitor Debio-025 Targets Crk, Reduces Metastasis, and Induces Tumor Immunogenicity in Breast Cancer
    Davra, Viralkumar
    Saleh, Tamjeed
    Geng, Ke
    Kimani, Stanley
    Mehta, Dhriti
    Kasikara, Canan
    Smith, Brendan
    Colangelo, Nicholas W.
    Ciccarelli, Bryan
    Li, Hong
    Azzam, Edouard I.
    Kalodimos, Charalampos G.
    Birge, Raymond B.
    Kumar, Sushil
    MOLECULAR CANCER RESEARCH, 2020, 18 (08) : 1189 - 1201
  • [10] In vitro Anti-hepatitis C Virus (HCV) Activities and Resistance Profile of Debio 025, A Non-immunosuppressive Cyclophilin Binding Molecule
    Coelmont, Lotte
    Gallay, Philippe
    Bobardt, Michael
    Kaptein, Suzanne
    Paeshuyse, Jan
    Vliegen, Inge
    Vuagniaux, Gregoire
    Neyts, Johan
    ANTIVIRAL RESEARCH, 2009, 82 (02) : A20 - A20
12345