Facile Nitrite Reduction in a Non-heme Iron System: Formation of an Iron(III)-Oxo

被引：91

作者：

Matson, Ellen M. ^{[1
]}

Park, Yun Ji ^{[1
]}

Fout, Alison R. ^{[1
]}

机构：

[1] Univ Illinois, Sch Chem Sci, Urbana, IL 61801 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2014年 / 136卷 / 50期

关键词：

NOX COMPOUNDS; COMPLEXES; DEOXYHEMOGLOBIN; OXIDE; ACTIVATION; MECHANISM; PORPHYRINS; EXPRESSION; MYOGLOBIN; OXIDATION;

D O I：

10.1021/ja510615p

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Reaction of tetrabutylammonium nitrite with [N(afa(Cy))(3)Fe(OTf)](OTf) cleanly resulted in the formation of an iron(III)-oxo species, [N(afa(Cy))(3)Fe(O)](OTf), and NO(g). Formation of NO(g) as a byproduct was confirmed by reaction of the iron(II) starting material with half an equivalent of nitrite, resulting in a mixture of two products, the iron-oxo and an iron-NO species, [N(afa(Cy))(3)Fe(NO)](OTf)(2). Formation of the latter was confirmed through independent synthesis. The results of this study provide insight into the role of hydrogen bonding in the mechanism of nitrite reduction and the binding mode of nitrite in biological heme systems.

引用

页码：17398 / 17401

页数：4

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