Two new isochondodendrine-type alkaloids from the roots of Anisocycla jollyana

Two new isochondodendrine-type alkaloids jollyanine (5) and fastrine (6) have been isolated from the roots of Anisocycla jollyana together with nine known alkaloids, (-)-cycleanine (1), (-)-isochondodendrine (2), (-)-norcycleanine (3), (-)-cycleanine N-oxide (4), (+)-dehydro-1,2 apateline, (+)-O-methyl-12 cocsoline, (+)-homoaromaline, (+)-limacusine, and (+)-limacusine-2'-beta-N-oxide. Their structures were elucidated by a combination of chemical and spectrometric methods including H-1-NMR, H-1-C-13 COSY, H-1-H-1 COSY, HMQC, and HMBC experiments. Compounds 5 and 6 represent the first isochondodendrine-type alkaloids bearing an oxygen substituent at the 5-position.