Successful salvage therapy for refractory primary cutaneous gamma-delta T-cell lymphoma with a combination of brentuximab vedotin and gemcitabine

被引：7
|
作者：
Voruz, Sophie [1 ]
de Leval, Laurence [2 ,3 ]
Cairoli, Anne [1 ]
机构：
[1] Univ Hosp Lausanne CHUV, Serv & Cent Lab Hematol, Rue Bugnon 46, CH-1011 Lausanne, Switzerland
[2] Lausanne Univ Hosp, Dept Lab Med & Pathol, Inst Pathol, Lausanne, Switzerland
[3] Lausanne Univ, Lausanne, Switzerland
来源：
EXPERIMENTAL HEMATOLOGY & ONCOLOGY | 2021年 / 10卷 / 01期
关键词：
Primary cutaneous gamma-delta T-cell lymphoma; Targeted treatment; Cutaneous T-cell lymphoma; Refractory disease; TRANSPLANTATION;
D O I：
10.1186/s40164-021-00225-2
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Primary cutaneous gamma-delta T-cell lymphoma (PCGD-TCL) is a very rare lymphoma with an aggressive clinical course and a dismal outcome. The prognosis is linked to a pronounced resistance to chemotherapy and radiotherapy. No standard treatment approach is defined due to the low frequency of the disease and lack of prospective studies. CD30 is expressed in almost half of the cases of PCGD-TCL, which offers a potential therapeutic option. We report the successful treatment of a 68-year-old man who suffered PCGD-TCL with a combination of Brentuximab Vedotin and Gemcitabine after the failure of two lines of previous chemotherapy. CD30 expression was only partial. The treatment was very well tolerated and allowed the patient to benefit from allogeneic hematopoietic stem cell transplantation.
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页数：4
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