Formulation and evaluation of ethyl cellulose microspheres prepared by the multiple emulsion technique

被引:4
|
作者
Kar, M. [1 ]
Choudhury, P. K. [1 ]
机构
[1] Mohan Lol Sakhadia Univ, Dept Pharmaceut Sci, Rajasthan 313001, India
来源
PHARMAZIE | 2007年 / 62卷 / 02期
关键词
D O I
10.1691/ph.2007.2.6062
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The aim of this study was to formulate and evaluate microencapsulated controlled release preparations of metformin hydrochloride using ethyl cellulose as the retardant material with high entrapment efficiency and extended release. Microspheres were prepared by the double emulsion solvent diffusion method. A mixed solvent system consisting of acetonitrile and dichloromethane in 1 : 1 ratio and light liquid paraffin were chosen as the primary and secondary oil phases, respectively. Span (R) 80 was used as the surfactant for stabilizing the secondary oil phase. The prepared microspheres were characterized by drug loading, optical microscopy and scanning electron microscopy (SEM). The in vitro release studies were performed in a series of buffer solutions with variable pH. The drug loaded microspheres showed 55-85% of entrapment and the release was extended for up to 12 h. SEM studies revealed that the microspheres were spherical and porous in nature. Data obtained from in vitro release studies were fitted to various kinetic models and high correlation was obtained with the Higuchi model. The drug release was found to be diffusion controlled. Oral administration of the microspheres to the albino mice provided decreased plasma glucose for more than 10 h.
引用
收藏
页码:122 / 125
页数:4
相关论文
共 50 条
  • [1] Formulation and in vitro evaluation of ethyl cellulose microspheres containing zidovudine
    Rao, KR
    Senapati, P
    Das, MK
    JOURNAL OF MICROENCAPSULATION, 2005, 22 (08) : 863 - 876
  • [2] Investigation on Processing Variables for the Preparation of Fluconazole-Loaded Ethyl Cellulose Microspheres by Modified Multiple Emulsion Technique
    Sabyasachi Maiti
    Paramita Dey
    Santanu Kaity
    Somasree Ray
    Sushomasri Maji
    Biswanath Sa
    AAPS PharmSciTech, 2009, 10 : 703 - 715
  • [3] Investigation on Processing Variables for the Preparation of Fluconazole-Loaded Ethyl Cellulose Microspheres by Modified Multiple Emulsion Technique
    Maiti, Sabyasachi
    Dey, Paramita
    Kaity, Santanu
    Ray, Somasree
    Maji, Sushomasri
    Sa, Biswanath
    AAPS PHARMSCITECH, 2009, 10 (03): : 703 - 715
  • [4] Preparation and in vitro evaluation of ethyl cellulose microspheres containing stavudine by the double emulsion method
    Sahoo, S. K.
    Mallick, A. A.
    Barik, B. B.
    Senapati, P. C.
    PHARMAZIE, 2007, 62 (02): : 117 - 121
  • [5] AN EVALUATION OF ALBUMIN MICROCAPSULES PREPARED USING A MULTIPLE EMULSION TECHNIQUE
    SHAH, MV
    DEGENNARO, MD
    SURYAKASUMA, H
    JOURNAL OF MICROENCAPSULATION, 1987, 4 (03) : 223 - 238
  • [6] Formulation and In-Vitro Evaluation of Repaglinide Microspheres Prepared by Spray Drying Technique
    Kshirsagar, Sanjay J.
    Patel, Smit J.
    Madgulkar, Ashwini R.
    Bhalekar, Mangesh R.
    LATIN AMERICAN JOURNAL OF PHARMACY, 2011, 30 (04): : 799 - 803
  • [7] Influence of formulation parameters on encapsulation of doxycycline in PLGA microspheres prepared by double emulsion technique for the treatment of periodontitis
    Ali, Muhanad
    Walboomers, X. Frank
    Jansen, John A.
    Yang, Fang
    JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2019, 52 : 263 - 271
  • [8] In vitro and in vivo evaluation of curcumin loaded hollow microspheres prepared with ethyl cellulose and citric acid
    Pi, Chao
    Yuan, Jiyuan
    Liu, Hao
    Zuo, Ying
    Feng, Ting
    Zhan, Chenglin
    Wu, Jun
    Ye, Yun
    Zhao, Ling
    Wei, Yumeng
    INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2018, 115 : 1046 - 1054
  • [9] FUROSEMIDE-LOADED ETHYL CELLULOSE MICROSPHERES PREPARED BY SPHERICAL CRYSTALLIZATION TECHNIQUE - MORPHOLOGY AND RELEASE CHARACTERISTICS
    AKBUGA, J
    INTERNATIONAL JOURNAL OF PHARMACEUTICS, 1991, 76 (03) : 193 - 198
  • [10] Formulation and In Vitro Evaluation of Telmisartan Nanoparticles Prepared by Emulsion-Solvent Evaporation Technique
    Ozturk, Naile
    Kara, Asli
    Vural, Imran
    TURKISH JOURNAL OF PHARMACEUTICAL SCIENCES, 2020, 17 (05) : 492 - 499