Current and future therapies for advanced pancreatic cancer

被引：147
|
作者：
Gupta, Rohan [1 ]
Amanam, Idoroenyi [1 ]
Chung, Vincent [1 ]
机构：
[1] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA
来源：
JOURNAL OF SURGICAL ONCOLOGY | 2017年 / 116卷 / 01期
关键词：
cytotoxic chemotherapy; pancreas cancer; vaccine therapy; TISSUE GROWTH-FACTOR; T-CELL IMMUNITY; STELLATE CELLS; NAB-PACLITAXEL; TGF-BETA; SPARC EXPRESSION; INDOLEAMINE 2,3-DIOXYGENASE; DESMOPLASTIC REACTION; ENZYMATIC DEPLETION; ANTITUMOR-ACTIVITY;
D O I：
10.1002/jso.24623
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Pancreatic cancer remains a deadly disease with a 5-year survival rate of only 8%. Even after surgical resection, most patients have recurrence of their cancer. Over the last 10 years, improvements in chemotherapy regimens led to a doubling in median overall survival. Here we review the management of advanced pancreatic cancer and highlight vaccine therapy as a novel modality of treatment.
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页码：25 / 34
页数：10
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