Capsaicin-sensitive sensory neurons contribute to the maintenance of trabecular bone integrity

被引：125
|
作者：
Offley, SC
Guo, TZ
Wei, TP
Clark, JD
Vogel, H
Lindsey, DP
Jacobs, CR
Yao, W
Lane, NE
Kingery, WS
机构：
[1] Vet Affairs Palo Alto Hlth Care Syst, Phys Med & Rehabil Serv 117, Palo Alto, CA 94304 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Anesthesiol Serv, Palo Alto, CA 94304 USA
[3] Stanford Univ, Sch Med, Dept Anesthesia, Stanford, CA 94305 USA
[4] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
[5] Vet Affairs Palo Alto Hlth Care Syst, Rehabil Res & Dev Ctr, Palo Alto, CA 94304 USA
[6] Stanford Univ, Sch Engn, Dept Engn Mech, Stanford, CA 94305 USA
[7] Stanford Univ, Sch Med, Dept Orthoped Surg, Stanford, CA 94305 USA
[8] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA
来源：
JOURNAL OF BONE AND MINERAL RESEARCH | 2005年 / 20卷 / 02期
关键词：
substance P; calcitonin gene-related peptide; capsaicin; osteoporosis; bone; BMD;
D O I：
10.1359/JBMR.041108
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
This investigation used capsaicin to selectively lesion unmyelinated sensory neurons in rats. Neuronal lesioning induced a loss of trabecular integrity, reduced bone mass and strength, and depleted neuropeptides in nerve and bone. These data suggest that capsaicin-sensitive sensory nerves contribute to trabecular bone integrity.
引用
收藏
页码：257 / 267
页数：11
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