Isolation, Synthesis, and Fungicidal Activity of Isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate Diastereomers against Phytophthora capsici

被引：0
|
作者：
Tian, Lei [1 ]
Gao, Yang [1 ]
Peng, Xing-Jie [1 ]
Zhang, Cheng [1 ]
Zhao, Wei-Guang [1 ]
Liu, Xing-Hai [2 ]
机构：
[1] Nankai Univ, State Key Lab Elemental Organ Chem, Tianjin 300071, Peoples R China
[2] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310014, Peoples R China
来源：
HETEROATOM CHEMISTRY | 2022年 / 2022卷
关键词：
ANTIFUNGAL ACTIVITY; DESIGN; DERIVATIVES;
D O I：
10.1155/2022/4678338
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Two isopropyl (3-methyl-1-oxo-1-((1-((4-(prop-2-yn-1-yloxy)phenyl)thio)propan-2-yl)amino)butan-2-yl)carbamate diastereomers were isolated. Fungicidal activities indicated that the isolated four chiral compounds possessed excellent activity against P. capsici with the EC50 value of 4a (1.30 mu g/mL), 4b (0.078 mu g/mL), 4c (1.85 mu g/mL), and 4d (44.4 mu g/mL). Among them, compound 4b exhibited remarkably high activities against Phytophthora capsici, which is better than that of positive control dimethomorph. Its R and S isomers showed that chiral influences the activity against P. capsici.
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页数：5
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