Bridging the gap between micro and nanotechnology: Using Lab-on-a-chip to enable nanosensors for genomics, proteomics, and diagnostic screening

The growing need for accurate and fast methods of DNA and protein determination in the post human genome era has generated considerable interest in the development of new microfluidic analytical platforms, fabricated using methods adapted from the semi-conductor industry. These methods have resulted in the development of the Lab-on-a-Chip concept, a technology which often involves having a miniaturised biochip (as an analytical device), with rather larger instrumentation associated with the control of the associated sensors and of fluidics. This talk will explore the development of new Lab-on-a-Chip platforms for DNA, protein and cell screening, using microfluidics as a packaging technology in order to enable advances in nanoscale science to be implemented in a Lab-on-a-Chip format. The talk will also show how system on a chip methods can be integrated with Lab-on-a-Chip devices to create remote and distributed intelligent sensors, which can be used in a variety of diagnostic applications, including for example chemical sensing within the GI tract.