Genetics of hereditary colon cancer -: a basis for prevention?

被引：12
|
作者：
Müller, HH [1 ]
Heinimann, K [1 ]
Dobbie, Z [1 ]
机构：
[1] Univ Basel, UKBB, DKBW, Res Grp Human Genet Devis Med Genet, CH-4005 Basel, Switzerland
来源：
EUROPEAN JOURNAL OF CANCER | 2000年 / 36卷 / 10期
关键词：
hamartoma polyposis syndromes; familial adenomatous polyposis; hereditary non-polyposis colorectal cancer; colon cancer prevention;
D O I：
10.1016/S0959-8049(00)00111-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Hereditary colorectal cancer syndromes are among the best in vivo models to study colorectal carcinogenesis and the influence of putative modifiers of the cancer risk. The present knowledge regarding the wide range of colorectal cancer (CRC) susceptibilities and the histological and molecular changes they elicit is leading to a very dynamic and integrated concept of tumorigenesis in the colon and to new views about prevention and early treatment of cancer. (C) 2000 Published by Elsevier Science Ltd. All rights reserved.
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页码：1215 / 1223
页数：9
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