In Vivo Functions of GPR30/GPER-1, a Membrane Receptor for Estrogen: From Discovery to Functions In Vivo

被引：81

作者：

Mizukami, Yoichi ^{[1
]}

机构：

[1] Yamaguchi Univ, Ctr Gene Res, Yamaguchi 7558505, Japan

来源：

ENDOCRINE JOURNAL | 2010年 / 57卷 / 02期

关键词：

GPR30; Membrane; GPCR; Estrogen; In vivo; PROTEIN-COUPLED RECEPTOR; BREAST-CANCER CELLS; HUMAN ENDOTHELIAL-CELLS; PLASMA-MEMBRANE; BLOOD-PRESSURE; GPR30; EXPRESSION; CLONING; GROWTH; MICE;

D O I：

10.1507/endocrj.K09E-332

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

G protein-coupled receptor 30/G protein-coupled estrogen receptor-1 (GPR30/GPER-1) was reported as a novel membrane receptor for estrogen in 2005. However, the research on GPR30 has produced conflicting reports with regard to its intracellular localization, the tissue distribution of its expression, and some its functions. Recently, in addition to the finding of G-1, a GPR30 agonist, GPR30 KO mice have been produced in laboratories, and this has significantly increased the confidence in the data. In this review, the intrinsic appearance of GPR30 is approached based mainly on data obtained in vivo.

引用

页码：101 / 107

页数：7

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