Tropoxin - Drug for the Treatment of Migraine

被引：1

作者：

Gan'shina, T. S. ^{[1
]}

Gorbunov, A. A. ^{[1
]}

Gnezdilova, A. V. ^{[1
]}

Turilova, A. I. ^{[1
]}

Kostochka, L. M. ^{[1
]}

Pyatin, B. M. ^{[1
]}

Avdyunina, N. I. ^{[1
]}

Grushevskaya, L. N. ^{[1
]}

Mirzoyan, R. S. ^{[1
]}

机构：

[1] VV Zakusov Sci Res Inst Pharmacol, 8 Baltiiskaya St, Moscow 125315, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2016年 / 50卷 / 01期

关键词：

migraine; Tropoxin; tropan derivatives; serotonin; meta-chlorophenylpiperazine; serotonin agonists; cerebral circulation; cerebral ischemia; HEADACHE; EFFICACY;

D O I：

10.1007/s11094-016-1391-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Anew antimigraine drug - Tropoxin (3-(3,4,5-trimethoxybenzoyloxyimino)-8-methyl-8-azabicyclo[1-3]octane hydrochloride) - was developed and was found to prevent or significantly weaken the constrictor reactions of cerebral arteries evoked by serotonin (5-HT) or the 5-HT2B/2C receptor agonist meta-chlorophenylpiperazine (m-CPP) in intact animals and in animals with ischemic brain damage. Tropoxin showed affinity for5-HT2 receptors in the brain and had antiaggregatory actions. It had no marked neurotropic properties and did not alter blood pressure responses to noradrenaline, acetylcholine, or histamine. Pilot clinical trials of Tropoxin provided evidence that it has high efficacy in the interictal treatment of frequent and severe migraine attacks.

引用

页码：19 / 23

页数：5

共 50 条

[1] Tropoxin – Drug for the Treatment of Migraine
T. S. Gan’shina
A. A. Gorbunov
A. V. Gnezdilova
A. I. Turilova
L. M. Kostochka
B. M. Pyatin
N. I. Avdyunina
L. N. Grushevskaya
R. S. Mirzoyan
Pharmaceutical Chemistry Journal, 2016, 50 : 19 - 23
[2] Drug treatment of migraine: Acute treatment and migraine prophylaxis
TfeltHansen, P
CURRENT OPINION IN NEUROLOGY, 1996, 9 (03) : 211 - 213
[3] DRUG-TREATMENT OF MIGRAINE
PFAFFENRATH, V
REITER, M
WIENER MEDIZINISCHE WOCHENSCHRIFT, 1988, 138 (23-24) : 591 - 599
[4] Prophylactic drug treatment of migraine
Massiou, H
Bousser, MG
REVUE NEUROLOGIQUE, 2005, 161 (6-7) : 681 - 684
[5] Acute drug treatment of migraine attack
M. C. Narbone
M. Abbate
S. Gangemi
Neurological Sciences, 2004, 25 : s113 - s118
[6] Acute drug treatment of migraine attack
Narbone, MC
Abbate, M
Gangemi, S
NEUROLOGICAL SCIENCES, 2004, 25 (Suppl 3) : S113 - S118
[7] The name of a drug used for the treatment of migraine
Mattsson, P
EUROPEAN JOURNAL OF PUBLIC HEALTH, 2002, 12 (02): : 155 - 155
[8] PROPHYLACTIC DRUG-TREATMENT OF MIGRAINE
MASSIOU, H
BOUSSER, MG
NEW TRENDS IN CLINICAL NEUROPHARMACOLOGY: CALCIUM ANATONISTS, ACUTE NEUROLOGY, HEADACHE AND MOVEMENT DISORDERS, 1988, 7 : 156 - 162
[9] DRUG-TREATMENT OF MIGRAINE HEADACHE
CALESNICK, B
AMERICAN FAMILY PHYSICIAN, 1982, 25 (05) : 228 - 230
[10] Drug safety in acute migraine treatment
Tajti, Janos
Majlath, Zsofia
Szok, Delia
Csati, Anett
Vecsei, Laszlo
EXPERT OPINION ON DRUG SAFETY, 2015, 14 (06) : 891 - 909

← 1 2 3 4 5 →