Semicarbazide: A Transient Directing Group for C(sp3)-H Arylation of 2-Methylbenzaldehydes

被引：23
|
作者：
Wen, Fei [1 ]
Li, Zheng [1 ]
机构：
[1] Northwest Normal Univ, Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2020年 / 362卷 / 01期
基金：
中国国家自然科学基金;
关键词：
semicarbazide; transient directing group; 2-methylbenzaldehyde; 2-benzylbenzaldehyde; C-H ARYLATION; UNSYMMETRICAL ACRIDINES; AMINO AMIDE; BENZALDEHYDES; FUNCTIONALIZATION; ALDEHYDES; ALKYLATION; GAMMA-C(SP(3))-H; DERIVATIVES; CYCLIZATION;
D O I：
10.1002/adsc.201901392
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Semicarbazide as an effective transient directing group for C(sp(3))-H arylation of 2-methylbenzaldehydes is described. Various substituted 2-benzylbenzaldehydes are efficiently synthesized by this strategy. The salient features of this protocol are the use of inexpensive transient directing group, wide scope of substrates with good functional group compatibility, up to 98% yield, and applicability to gram scale.
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页码：133 / 138
页数：6
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