Diagnostic criteria for apathy in neurocognitive disorders

被引：82

作者：

Miller, David S. ^{[1
]}

Robert, Philippe ^{[2
,3
,4
]}

Ereshefsky, Larry ^{[5
]}

Adler, Lawrence ^{[6
]}

Bateman, Daniel ^{[7
]}

Cummings, Jeff ^{[8
,9
]}

DeKosky, Steven T. ^{[10
]}

Fischer, Corinne E. ^{[11
,12
]}

Husain, Masud ^{[13
,14
,15
]}

Ismail, Zahinoor ^{[16
]}

Jaeger, Judith ^{[17
]}

Lerner, Alan J. ^{[18
]}

Li, Abby ^{[19
]}

Lyketsos, Constantine G. ^{[20
]}

Manera, Valeria ^{[2
,3
]}

Mintzer, Jacobo ^{[21
,22
]}

Moebius, Hans J. ^{[23
]}

Mortby, Moyra ^{[24
]}

Meulien, Didier ^{[25
]}

Pollentier, Stephane ^{[26
]}

Porsteinsson, Anton ^{[27
]}

Rasmussen, Jill ^{[28
]}

Rosenberg, Paul B. ^{[20
]}

Ruthirakuhan, Myuri T. ^{[19
]}

Sano, Mary ^{[29
]}

Sarracini, Carla Zucchero ^{[19
]}

Lanctot, Krista L. ^{[19
,30
,31
]}

机构：

[1] Signant Health, Blue Bell, PA USA

[2] Univ Cote dAzur, Cognit Behav Technol Lab, Nice, France

[3] Assoc Innovat Alzheimer, Nice, France

[4] Univ Nice, Ctr Memoire, Ctr Hosp, Nice, France

[5] Follow Mol, Marina Del Rey, CA USA

[6] Univ Maryland, Sch Med, Dept Psychiat, Baltimore, MD 21201 USA

[7] Indiana Univ Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA

[8] Univ Nevada, Sch Integrated Hlth Sci, Dept Brain Hlth, Las Vegas, NV USA

[9] Cleveland Clin, Lou Ruvo Ctr Brain Hlth, Las Vegas, NV USA

[10] Univ Florida, Dept Neurol, McKnight Brain Inst, Gainesville, FL USA

[11] Univ Toronto, Inst Med Sci, Toronto, ON, Canada

[12] St Michaels Hosp, Li Ka Shing Knowledge Inst, Keenan Res Ctr Biomed Res, Toronto, ON, Canada

[13] Univ Oxford, Dept Expt Psychol, Oxford, England

[14] Univ Oxford, Nuffield Dept Clin Neurosci, Oxford, England

[15] Oxford NIHR Biomed Res Ctr, Oxford, England

[16] Univ Calgary, Hotchkiss Brain Inst, Calgary, AB, Canada

[17] CognitionMetrics, Wilmington, DE USA

[18] Case Western Reserve Univ, Univ Hosp, Cleveland, OH USA

[19] Sunnybrook Res Inst, Toronto, ON, Canada

[20] Johns Hopkins Univ, Baltimore, MD USA

[21] Med Univ South Carolina, Charleston, SC 29425 USA

[22] Ralph H Johnson Vet Adm Med Ctr, Charleston, SC USA

[23] Moebius Consult, Baar, Switzerland

[24] Univ New South Wales, UNSW Ageing Futures Inst, Sydney, NSW, Australia

[25] H Lundbeck & Co AS, Clin Res & Dev, Valby, Denmark

[26] Boehringer Ingelheim Pharma GmbH & Co KG, CNS Dis Res, Biberach, Germany

[27] Univ Rochester, Rochester, NY USA

[28] Psi Napse, Dorking, Surrey, England

[29] Icahn Sch Med Mt Sinai, Dept Psychiat, Alzheimer Dis Res Ctr, New York, NY USA

[30] Univ Toronto, Dept Psychiat, Toronto, ON, Canada

[31] Univ Toronto, Dept Pharmacol Toxicol, Toronto, ON, Canada

来源：

ALZHEIMERS & DEMENTIA | 2021年 / 17卷 / 12期

关键词：

apathy; behavior; cognition; diagnostic criteria; emotion; motivation; neurocognitive disorder (NCD); neuropsychiatric symptoms (NPS); MILD COGNITIVE IMPAIRMENT; NURSING-HOME RESIDENTS; DISEASE RATING-SCALE; ALZHEIMERS-DISEASE; NEUROPSYCHIATRIC SYMPTOMS; PARKINSONS-DISEASE; FRONTOTEMPORAL DEMENTIA; NONPHARMACOLOGICAL TREATMENT; PSYCHOMETRIC PROPERTIES; AMYLOID BURDEN;

D O I：

10.1002/alz.12358

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Apathy is common in neurocognitive disorders (NCD) but NCD-specific diagnostic criteria are needed. Methods The International Society for CNS Clinical Trials Methodology Apathy Work Group convened an expert group and sought input from academia, health-care, industry, and regulatory bodies. A modified Delphi methodology was followed, and included an extensive literature review, two surveys, and two meetings at international conferences, culminating in a consensus meeting in 2019. Results The final criteria reached consensus with more than 80% agreement on all parts and included: limited to people with NCD; symptoms persistent or frequently recurrent over at least 4 weeks, a change from the patient's usual behavior, and including one of the following: diminished initiative, diminished interest, or diminished emotional expression/responsiveness; causing significant functional impairment and not exclusively explained by other etiologies. Discussion These criteria provide a framework for defining apathy as a unique clinical construct in NCD for diagnosis and further research.

引用

页码：1892 / 1904

页数：13

共 50 条

[1] Diagnostic criteria for apathy revisited
Robert, P.
[J]. EUROPEAN PSYCHIATRY, 2018, 48 : S26 - S26
[2] Comparing diagnostic criteria for the diagnosis of neurocognitive disorders in multiple sclerosis
Hancock, Laura M.
Hermann, Bruce
Schoonheim, Menno M.
Hetzel, Scott J.
Brochet, Bruno
DeLuca, John
[J]. MULTIPLE SCLEROSIS AND RELATED DISORDERS, 2022, 58
[3] Research diagnostic criteria for neurocognitive disorders using the biomarker approach
Sachdev, P.
[J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 2019, 405
[4] Proposed diagnostic criteria for apathy in Alzheimer's disease and other neuropsychiatric disorders
Robert, P.
Onyike, C. U.
Leentjens, A. F. G.
Dujardin, K.
Aalten, P.
Starkstein, S.
Verhey, F. R. J.
Yessavage, J.
Clement, J. P.
Drapier, D.
Bayle, F.
Benoit, M.
Boyer, P.
Lorca, P. M.
Thibaut, F.
Gauthier, S.
Grossberg, G.
Vellas, B.
Byrne, J.
[J]. EUROPEAN PSYCHIATRY, 2009, 24 (02) : 98 - 104
[5] Diagnostic criteria for apathy in clinical practice
Mulin, E.
Leone, E.
Dujardin, K.
Delliaux, M.
Leentjens, A.
Nobili, F.
Dessi, B.
Tible, O.
Agueera-Ortiz, L.
Osorio, R. S.
Yessavage, J.
Dachevsky, D.
Verhey, F. R. J.
Cruz Jentoft, A. J.
Blanc, O.
Llorca, P. M.
Robert, P. H.
[J]. INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2011, 26 (02) : 158 - 165
[6] Is it time to revise the diagnostic criteria for apathy in brain disorders? The 2018 international consensus group
Robert, P.
Lanctot, K. L.
Aguera-Ortiz, L.
Aalten, P.
Bremond, F.
Defrancesco, M.
Hanon, C.
David, R.
Dubois, B.
Dujardin, K.
Husain, M.
Konig, A.
Levy, R.
Mantua, V.
Meulien, D.
Miller, D.
Moebius, H. J.
Rasmussen, J.
Robert, G.
Ruthirakuhan, M.
Stella, F.
Yesavage, J.
Zeghari, R.
Manera, V.
[J]. EUROPEAN PSYCHIATRY, 2018, 54 : 71 - 76
[7] DIAGNOSTIC CRITERIA FOR DEMENTIA, MODERATE AND MILD NEUROCOGNITIVE DISORDERS IN NEUROLOGICAL PATIENTS: LINGUISTIC PARTS OF BASELINE NEUROCOGNITIVE TESTS
Esin, Rady
Gorobets, Elena
Tokareva, Nailya
Karimullina, Rezeda
Khairullin, Ilshat
Mingazova, Leisan
[J]. PSYCHOLOGY AND PSYCHIATRY, SOCIOLOGY AND HEALTHCARE, EDUCATION, VOL I, 2014, : 121 - 128
[8] A Systematic Review of Pharmacological Interventions for Apathy in Aging Neurocognitive Disorders
Theleritis, Christos
Siarkos, Kostas
Politis, Anastasios
Smyrnis, Nikolaos
Papageorgiou, Charalabos
Politis, Antonios M.
[J]. BRAIN SCIENCES, 2023, 13 (07)
[9] Apathy associated with neurocognitive disorders: Recent progress and future directions
Lanctot, Krista L.
Aguera-Ortiz, Luis
Brodaty, Henry
Francis, Paul T.
Geda, Yonas E.
Ismail, Zahinoor
Marshall, Gad A.
Mortby, Moyra E.
Onyike, Chiadi U.
Padala, Prasad R.
Politis, Antonios M.
Rosenberg, Paul B.
Siegel, Emma
Sultzer, David L.
Abraham, Eleenor H.
[J]. ALZHEIMERS & DEMENTIA, 2017, 13 (01) : 84 - 100
[10] Validation of diagnostic criteria for apathy in Parkinson's disease
Drijgers, Rosa L.
Dujardin, Kathy
Reijnders, Jennifer S. A. M.
Defebvre, Luc
Leentjens, Albert F. G.
[J]. PARKINSONISM & RELATED DISORDERS, 2010, 16 (10) : 656 - 660

← 1 2 3 4 5 →