From terminal alkynes directly to branched amines

被引：31
|
作者：
Castro, IG [1 ]
Tillack, A [1 ]
Hartung, CG [1 ]
Beller, M [1 ]
机构：
[1] Univ Rostock eV, Leibniz Inst Organ Katalyse IfOK, D-18055 Rostock, Germany
来源：
TETRAHEDRON LETTERS | 2003年 / 44卷 / 15期
关键词：
D O I：
10.1016/S0040-4039(03)00448-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The one-pot synthesis of several branched secondary aliphatic amines is described. Hydroamination of terminal alkynes with aliphatic primary amines in the presence of Cp2Ti(eta(2)-Me(3)SiCequivalent toCSiMe(3)) gives the corresponding aldimines as intermediates. Reaction of these in situ produced aldimines with organolithium reagents (n-BuLi, PhLi) provides the alpha-branched amines in an easy way in upto 78% overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：3217 / 3221
页数：5
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