Distribution of HPV types associated with cervical cancers in Scotland and implications for the impact of HPV vaccines

被引：18
|
作者：
Cuschieri, K. [1 ]
Brewster, D. H. [2 ]
Williams, A. R. W. [3 ]
Millan, D. [4 ]
Murray, G. [5 ]
Nicoll, S. [6 ]
Imrie, J. [7 ]
Hardie, A. [1 ]
Graham, C. [8 ]
Cubie, H. A. [1 ]
机构：
[1] Royal Infirm Edinburgh NHS Trust, Specialist Virol Ctr, Scottish HPV Reference Lab, Edinburgh EH16 4SA, Midlothian, Scotland
[2] NHS Natl Serv Scotland, Informat Serv Div, Scottish Canc Registry, Edinburgh EH12 9EB, Midlothian, Scotland
[3] Royal Infirm Edinburgh NHS Trust, Dept Pathol, Edinburgh EH16 4SA, Midlothian, Scotland
[4] Glasgow Royal Infirm, Dept Pathol, Glasgow G4 0SF, Lanark, Scotland
[5] Aberdeen Royal Infirm, Dept Pathol, Aberdeen AB25 2ZN, Scotland
[6] Ninewells Hosp, Dept Pathol, Dundee DD1 9SY, Scotland
[7] Monklands Gen Hosp, Dept Cytopathol, Airdrie ML6 OJS, Scotland
[8] Wellcome Trust Clin Res Facil, Edinburgh EH4 2XU, Midlothian, Scotland
来源：
BRITISH JOURNAL OF CANCER | 2010年 / 102卷 / 05期
关键词：
HPV; genotyping; Scotland; LESIONS;
D O I：
10.1038/sj.bjc.6605556
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
BACKGROUND/METHODS: This study evaluated human papillomavirus (HPV) type prevalence in 370 Scottish invasive cervical cancers (ICCs) using HPV genotyping and HPV mRNA detection. RESULTS: HPV 16 and/or 18 was detected in 72% of cancers overall and in 82% of HPV-positive cancers. HPV 45 and 16 were the most frequently transcribed types. CONCLUSION: A significant reduction in ICC in Scotland should be achieved through the HPV immunisation programme. British Journal of Cancer (2010) 102, 930-932. doi: 10.1038/sj.bjc.6605556 www.bjcancer.com Published online 9 February 2010 (C) 2010 Cancer Research UK
引用
收藏
页码：930 / 932
页数：3
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