Y-shaped RNA secondary structure of a noncoding region in the genomic RNA of tick-borne encephalitis virus affects pathogenicity

被引：1

作者：

Nishiyama, Shoko ^{[1
]}

Hirano, Minato ^{[2
,3
]}

Muto, Memi ^{[2
]}

Kambara, Mao ^{[2
]}

Ito, Naoto ^{[1
]}

Kobayashi, Shintaro ^{[2
]}

Kariwa, Hiroaki ^{[2
]}

Yoshii, Kentaro ^{[2
,3
]}

机构：

[1] Gifu Univ, Fac Appl Biosci, Joint Dept Vet Med, Lab Zoonot Dis, Gifu, Japan

[2] Hokkaido Univ, Grad Sch Vet Med, Lab Publ Hlth, Sapporo, Hokkaido, Japan

[3] Nagasaki Univ, Natl Res Ctr Control & Prevent Infect Dis, 1-12-4 Sakamoto, Nagasaki 8528523, Japan

来源：

MICROBIOLOGY AND IMMUNOLOGY | 2022年 / 66卷 / 05期

关键词：

subgenomic flavivirus RNA; tick; tick-borne encephalitis virus; untranslated region; MOLECULAR CHARACTERIZATION; STRAINS; SEQUENCES; VIRULENCE; DELETIONS; RESISTANT; MUTANTS;

D O I：

10.1111/1348-0421.12971

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tick-borne encephalitis virus (TBEV) is a zoonotic virus that causes encephalitis in humans. Various deletions have been reported in a variable region of the 3 ' untranslated region of the TBEV genome. This study analyzed the role of a Y-shaped secondary structure in the pathogenicity of TBEV by using reverse genetics. Deletion of the structure increased the mortality rate of virus-infected mice but did not affect the virus multiplication in cultured cells and organs. The results indicate that the secondary structure is involved in the regulation of TBEV pathogenesis.

引用

页码：234 / 237

页数：4

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