Radium-223 in Metastatic Castration-Resistant Prostate Cancer: Clinical Development and Use in Contemporary Practice

被引：3
|
作者：
Morgan, Scott C. [1 ,2 ]
机构：
[1] Ottawa Hosp Canc Ctr, Div Radiat Oncol, 501 Smyth Rd,Box 903, Ottawa, ON K1H 8L6, Canada
[2] Univ Ottawa, Dept Radiol, Div Radiat Oncol, Ottawa, ON, Canada
来源：
JOURNAL OF MEDICAL IMAGING AND RADIATION SCIENCES | 2019年 / 50卷 / 04期
关键词：
Alpha particles; radioisotopes; castration-resistant prostate cancer; bone metastases; INCREASED SURVIVAL; OPEN-LABEL; ENZALUTAMIDE; DICHLORIDE; THERAPY; ABIRATERONE; CARE; MEN;
D O I：
10.1016/j.jmir.2019.05.006
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Radium-223 is a first-in-class alpha particle-emitting radionuclide. Unlike the beta emitters whose development preceded it and whose use has largely been limited to symptom palliation, radium-223 has been shown to meaningfully alter the natural history of bonepredominant metastatic castration-resistant prostate cancer and improve overall survival. This review-a precis of a lecture given at the Eleventh International Symposium on Targeted Alpha Therapy in April 2019-discusses the radiobiological properties of radium-223, summarizes its clinical development over the past decade, and situates it in the current therapeutic landscape for metastatic castration-resistant prostate cancer.
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页码：S26 / S30
页数：5
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