WNT signaling in bone development and homeostasis

被引：104
|
作者：
Zhong, Zhendong [1 ]
Ethen, Nicole J. [1 ]
Williams, Bart O. [1 ]
机构：
[1] Van Andel Res Inst, Ctr Skeletal Dis & Tumor Microenvironm, Grand Rapids, MI 49503 USA
来源：
WILEY INTERDISCIPLINARY REVIEWS-DEVELOPMENTAL BIOLOGY | 2014年 / 3卷 / 06期
关键词：
RECEPTOR-RELATED PROTEIN-5; MICE DEFICIENT; BETA-CATENIN; MUTATIONS; LRP5; MASS; GENE; SCLEROSTIN; OSTEOBLAST; DENSITY;
D O I：
10.1002/wdev.159
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The balance between bone formation and bone resorption controls postnatal bone homeostasis. Research over the last decade has provided a vast amount of evidence that WNT signaling plays a pivotal role in regulating this balance. Therefore, understanding how the WNT signaling pathway regulates skeletal development and homeostasis is of great value for human skeletal health and disease. (C) 2014 Wiley Periodicals, Inc.
引用
收藏
页码：489 / 500
页数：12
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