Role of left ventricular systolic and diastolic dysfunction in clinical manifestations of chronic heart failure and in patients with prior myocardial infarction

Aim. To study the impact of systolic and systolic dysfunction of the left ventricle (LV) on the clinical manifestations of chronic heart failure (HF) in patients with prior myocardial infarction (MI). Materials and methods. 102 patients (mean age 47.4 +/- 0.7 years) who had sustained large focal IM at least 6 months before were examined. LV echocardiography was made to define systolic-diastolic relationships in HF. Results. Analyzing the prevalence of primary diastolic HF in patients with its different clinical manifestations, it may be concluded that LV diastolic dysfunction is of the leading pathogenetic value at. early stages of ischemic heart dysfunction. A complex relationship between the clinical Manifestations of HF and a number of parameters characterizing the. systolic and diastolic function of LV was estimated by the multiple regression analysis and presented as a trinomial equation. Conclusion. The results of the regression analysis have shown that the clinical manifestation of HF intensifies as relaxation slows down and transmittal blood flow redistributes to the left atrial systole; the severity of HF also increases with the depletion of compensatory mechanisms responsible for LV contractility.