Innovative treatment of acute migraine pain with CGRP receptor antagonists

被引：1
|
作者：
Herbert, MK
Holzer, P
机构：
[1] Univ Wurzburg, Klin & Polklin Anasthesiol, D-97080 Wurzburg, Germany
[2] Med Univ Graz, Inst Expt & Klin Pharmakol, Graz, Austria
来源：
ANASTHESIOLOGIE INTENSIVMEDIZIN NOTFALLMEDIZIN SCHMERZTHERAPIE | 2004年 / 39卷 / 11期
关键词：
CGRP receptor antagonist; BIBN4096BS; migraine; neurogenic inflammation; triptans;
D O I：
10.1055/s-2004-826037
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Neurogenic inflammation caused by the release of vasoactive neuropeptides such as calcitonin gene-related peptide (CGRP) from nociceptive perivascular nerve fibres has been implicated in the development of acute migraine pain. It has recently been demonstrated that the CGRP receptor antagonist BIBN 4096 BS significantly reduces acute pain in migraine. This therapeutic efficacy provides further evidence for a critical role of CGRP in the pathophysiology of migraine. Given the apparent absence of vasoconstrictor activity both in meningeal and extracranial vessels, BIBN 4096 BS may provide an alternative for the treatment of migraine in those patients where triptans and ergotamine derivatives are contraindicated due to their side effects.
引用
收藏
页码：657 / 661
页数：7
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