Phase I Study of Second Generation Chimeric Antigen Receptor-Engineered T Cells Targeting IL13Rα2 for the Treatment of Glioblastoma

被引：3
|
作者：
Brown, Christine E. [1 ]
Starr, Renate [1 ]
Weng, Lihong [1 ]
Alizadeh, Darya [1 ]
Wagner, Jamie R. [1 ]
Kilpatrick, Julie [1 ]
Harshbarger, Todd L. [1 ]
D'Apuzzo, Massimo [1 ]
Ressler, Julie A. [1 ]
Jensen, Michael C. [2 ]
Portnow, Jana [1 ]
Barish, Michael E. [1 ]
Forman, Stephen J. [1 ]
Badie, Behnam [1 ]
机构：
[1] City Hope Natl Med Ctr, Duarte, CA USA
[2] Seattle Childrens Res Inst, Seattle, WA USA
来源：
MOLECULAR THERAPY | 2016年 / 24卷
关键词：
D O I：
10.1016/S1525-0016(16)33056-8
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
247
引用
收藏
页码：S97 / S97
页数：1
相关论文
共 50 条
  • [1] PHASE I STUDY OF CHIMERIC ANTIGEN RECEPTOR-ENGINEERED T CELLS TARGETING IL13Rα2 FOR THE TREATMENT OF GLIOBLASTOMA
    Brown, Christine
    Alizadeh, Darya
    Starr, Renate
    Weng, Lihong
    Wagner, Jamie
    Naranjo, Araceli
    Blanchard, Suzette
    Kilpatrick, Julie
    Simpson, Jennifer
    Ressler, Julie Ann
    Jensen, Michael
    Portnow, Jana
    D'Apuzzo, Massimo
    Barish, Michael
    Forman, Stephen
    Badie, Behnam
    [J]. NEURO-ONCOLOGY, 2016, 18 : 20 - 20
  • [2] IL13Rα2 chimeric antigen receptor T cells combined with checkpoint blockade to treat glioblastoma in human and canine models
    Yin, Y.
    Binder, Z.
    Thokala, R.
    O'Rourke, D.
    [J]. EUROPEAN JOURNAL OF CANCER, 2018, 103 : E57 - E57
  • [3] Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer
    Victoria Hillerdal
    Magnus Essand
    [J]. BioDrugs, 2015, 29 : 75 - 89
  • [4] Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Metastatic Prostate Cancer
    Hillerdal, Victoria
    Essand, Magnus
    [J]. BIODRUGS, 2015, 29 (02) : 75 - 89
  • [5] Bioactivity and Safety of IL13Rα2-Redirected Chimeric Antigen Receptor CD8+ T Cells in Patients with Recurrent Glioblastoma
    Brown, Christine E.
    Badie, Behnam
    Barish, Michael E.
    Weng, Lihong
    Ostberg, Julie R.
    Chang, Wen-Chung
    Naranjo, Araceli
    Starr, Renate
    Wagner, Jamie
    Wright, Christine
    Zhai, Yubo
    Bading, James R.
    Ressler, Julie A.
    Portnow, Jana
    D'Apuzzo, Massimo
    Forman, Stephen J.
    Jensen, Michael C.
    [J]. CLINICAL CANCER RESEARCH, 2015, 21 (18) : 4062 - 4072
  • [6] Adoptive Transfer of IL13Rα2-Specific Chimeric Antigen Receptor T Cells Creates a Pro-inflammatory Environment in Glioblastoma
    Pituch, Katarzyna C.
    Miska, Jason
    Krenciute, Giedre
    Panek, Wojciech K.
    Li, Gina
    Rodriguez-Cruz, Tania
    Wu, Meijing
    Han, Yu
    Lesniak, Maciej S.
    Gottschalk, Stephen
    Balyasnikova, Irina V.
    [J]. MOLECULAR THERAPY, 2018, 26 (04) : 986 - 995
  • [7] Optimization of IL13Rα2-Targeted Chimeric Antigen Receptor T Cells for Improved Anti-tumor Efficacy against Glioblastoma
    Brown, Christine E.
    Aguilar, Brenda
    Starr, Renate
    Yang, Xin
    Chang, Wen-Chung
    Weng, Lihong
    Chang, Brenda
    Sarkissian, Aniee
    Brito, Alfonso
    Sanchez, James F.
    Ostberg, Julie R.
    D'Apuzzo, Massimo
    Badie, Behnam
    Barish, Michael E.
    Forman, Stephen J.
    [J]. MOLECULAR THERAPY, 2018, 26 (01) : 31 - 44
  • [8] Improved Chimeric Antigen Receptor-Engineered T Cells for the Treatment of Refractory and Relapsed Leukemia
    Chang, Lung-Ji
    Dong, Lujia
    Guo, Hao-Hsiang
    Zhang, Jian-Ping
    Gao, Zhi-Yung
    Li, Wei-Da
    Cui, Jiuwei
    Li, Wei
    Lu, Daopei
    [J]. MOLECULAR THERAPY, 2014, 22 : S296 - S297
  • [9] Targeting IL13R alpha2 heterogeneity in malignant glioma with engineered T cells
    Sengupta, Sadhak
    Balyasnikova, Irina
    Naheed, Seema
    Lesniak, Maciej S.
    Junghans, Richard P.
    Sampath, Prakash
    [J]. CANCER RESEARCH, 2014, 74 (19)
  • [10] Chimeric Antigen Receptor T Cells With Modified Interleukin-13 Preferentially Recognize IL13Rα2 and Suppress Malignant Glioma: A Preclinical Study
    Kim, Kiwan
    Gwak, Ho-Shin
    Han, Nayoung
    Hong, Eun Kyung
    Choi, Beom K.
    Lee, Sangeun
    Choi, Soyoung
    Park, Ju-Hwang
    Seok, Ji-Hye
    Jeon, Yeongha
    Cho, Hyuntae
    Lee, Song-Jae
    Lee, Yura
    Nam, Ki Taek
    Song, Seong-Won
    [J]. FRONTIERS IN IMMUNOLOGY, 2021, 12
12345