RETRACTED: Effects of Different Doses of Clopidogrel plus Early Rehabilitation Therapy on Motor Function and Inflammatory Factors in Patients with Ischemic Stroke (Retracted Article)

被引:1
|
作者
Zhao, Zhuolin [1 ]
Ma, Ying [2 ]
Liu, Qin [1 ]
Jiang, Ling [1 ]
Shu, Huimin [1 ]
Chen, Daofeng [1 ]
Wu, Jiao [3 ]
机构
[1] Second Peoples Hosp Yibin, Dept Neurol, Yibin, Peoples R China
[2] North Sichuan Med Coll, Dept Neurol, Nanchong, Peoples R China
[3] Second Peoples Hosp Yibin, Dept Neurosurg, Yibin, Peoples R China
关键词
INJURY;
D O I
10.1155/2022/9692382
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
This prospective randomized controlled study was intended to assess the effects of different doses of clopidogrel plus early rehabilitation therapy on motor function and inflammatory factors in patients with ischemic stroke. Between August 2018 and October 2020, 90 cases of ischemic stroke treated in the Second People's Hospital of Yibin were randomized at a ratio of 1 : 1 to receive either oral 50 mg/d clopidogrel plus early rehabilitation therapy (low-dose group) or oral 75 mg/d clopidogrel plus early rehabilitation therapy (high-dose group), with 45 cases in each group. The outcome measures including the Barthel Index (BI), National Institutes of Health Stroke Scale (NIHSS), Fugl-Meyer simplified scale, hypersensitive C-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and occurrence of adverse events were collected. After treatment, the high-dose group had higher BI results than the low-dose group. All eligible patients showed significantly declined NIHSS scores, and the high-dose group had markedly lower results (P < 0.05). After treatment, the Fugl-Meyer scores of both upper and lower extremities of the high-dose group were significantly higher than those in the low-dose group. The high-dose group achieved a greater decrease in inflammatory factor levels after treatment versus the low-dose group. The two groups showed a similar incidence of adverse events. High-dose clopidogrel plus early rehabilitation outperforms the low-dose treatment for patients with ischemic stroke by effectively mitigating the inflammatory response in the body, promoting the restoration of neurological function, improving the level of motor function, and enhancing the patient's quality of life, with manageable safety.
引用
收藏
页数:6
相关论文
共 50 条
  • [1] RETRACTED: Effect of Acupuncture and Rehabilitation Therapy on the Recovery of Neurological Function and Prognosis of Stroke Patients (Retracted Article)
    Fu, Lanping
    Wang, Fei
    Ma, Zhiyi
    Zhang, Jin
    Xiong, Wuzhong
    Wang, Le
    [J]. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2022, 2022
  • [2] RETRACTED: Effects of Different Intervention Time Points of Early Rehabilitation on Patients with Acute Ischemic Stroke: A Single-Center, Randomized Control Study (Retracted Article)
    Liu, LiLi
    Lu, YanQin
    Bi, QianQian
    Fu, Wang
    Zhou, XiaoYu
    Wang, Jue
    [J]. BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [3] RETRACTED: Effect of Alteplase Thrombolysis on Coagulation Function and Nerve Function of Patients with Ischemic Stroke (Retracted Article)
    Zhao, Hong-Ying
    Yang, Guo-Tao
    Zhang, Hui-Fang
    Wang, Wen-Hao
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [4] RETRACTED: Effects of Different Doses of Dex Anesthesia on Inflammatory Factors and Hemodynamics in Patients Undergoing Neurosurgery and Its Relationship with RSS Score (Retracted Article)
    Lu, Qiaoling
    Wu, Chengwei
    Wu, Zhenhua
    Wang, Xinbin
    Cheng, Hao
    [J]. BIOMED RESEARCH INTERNATIONAL, 2022, 2022
  • [5] RETRACTED: Effects of a Brain-Computer Interface-Operated Lower Limb Rehabilitation Robot on Motor Function Recovery in Patients with Stroke (Retracted Article)
    Li, Chao
    Wei, Jinyu
    Huang, Xiaoqun
    Duan, Qiang
    Zhang, Tingting
    [J]. JOURNAL OF HEALTHCARE ENGINEERING, 2021, 2021
  • [6] RETRACTED: Effects of Acupuncture Combined with Biofeedback Therapy on Limb Motor Rehabilitation in Patients with Acute Stroke: Systematic Review and Meta-Analysis (Retracted Article)
    Song, Xinrong
    Zhang, Xiaoge
    Weng, Yan
    Liu, Yu
    Shan, Qi
    Chen, Wenna
    Ma, Wanwan
    Dong, Qi
    Qu, Dandan
    Guo, Yibo
    Xiong, Jie
    Deng, Fuhua
    Fu, Qizhi
    Xin, Yufu
    [J]. BIOMED RESEARCH INTERNATIONAL, 2022, 2022
  • [7] RETRACTED: Effective Analysis of Multichannel Functional Electrical Stimulation plus Early Rehabilitation Training for Hemiplegic Patients after Stroke (Retracted Article)
    Hou, Yan
    Yang, Li
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2022, 2022
  • [8] RETRACTED: Effects of Early Acupuncture Combined with Rehabilitation Training on Limb Function and Nerve Injury Rehabilitation in Elderly Patients with Stroke: Based on a Retrospective Cohort Study (Retracted Article)
    Zhang, Ping
    Jiang, Guiling
    Wang, Qian
    Wang, Ying
    Ma, Yihong
    Li, Simin
    Li, Xiubin
    Li, Hu
    Xing, Xiaomin
    Xu, Yuzhen
    [J]. BIOMED RESEARCH INTERNATIONAL, 2022, 2022
  • [9] RETRACTED: Potential Factors for Psychological Symptoms at Three Months in Patients with Young Ischemic Stroke (Retracted Article)
    Xu, Dongjuan
    Chu, Xi
    Wang, Kun
    Wei, Lianyan
    Xu, Yunyun
    Huang, Xiaomin
    Li, Jinna
    Xu, Lina
    Yin, Lu
    Liu, Hong
    Liu, Xiaolei
    Leng, Haixia
    Xue, Qing
    Peng, Mao
    Jia, Longbin
    Wang, Hongxing
    [J]. BIOMED RESEARCH INTERNATIONAL, 2021, 2021
  • [10] RETRACTED: Effects of Neuromuscular Electrical Stimulation Combined with Repetitive Transcranial Magnetic Stimulation on Upper Limb Motor Function Rehabilitation in Stroke Patients with Hemiplegia (Retracted Article)
    Du, Junqiu
    Wang, Shouyong
    Cheng, Yun
    Xu, Jiang
    Li, Xuejing
    Gan, Yimin
    Zhang, Liying
    Zhang, Song
    Cui, Xiaorui
    [J]. COMPUTATIONAL AND MATHEMATICAL METHODS IN MEDICINE, 2022, 2022