Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations

被引:1635
|
作者
Greenland, Sander [1 ,2 ]
Senn, Stephen J. [3 ]
Rothman, Kenneth J. [4 ]
Carlin, John B. [5 ]
Poole, Charles [6 ]
Goodman, Steven N. [7 ,8 ]
Altman, Douglas G. [9 ]
机构
[1] Univ Calif Los Angeles, Dept Epidemiol, Los Angeles, CA USA
[2] Univ Calif Los Angeles, Dept Stat, Los Angeles, CA USA
[3] Luxembourg Inst Hlth, Competence Ctr Methodol & Stat, Strassen, Luxembourg
[4] Res Triangle Inst, RTI Hlth Solut, POB 12194, Res Triangle Pk, NC 27709 USA
[5] Univ Melbourne, Sch Populat Hlth, Murdoch Childrens Res Inst, Clin Epidemiol & Biostat Unit, Melbourne, Vic, Australia
[6] Univ N Carolina, Gillings Sch Global Publ Hlth, Dept Epidemiol, Chapel Hill, NC USA
[7] Stanford Univ, Sch Med, Meta Res Innovat Ctr, Dept Med, Stanford, CA 94305 USA
[8] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA
[9] Univ Oxford, Ctr Stat Med, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
关键词
Confidence intervals; Hypothesis testing; Null testing; P value; Power; Significance tests; Statistical testing; NULL-HYPOTHESIS; CLINICAL-TRIALS; SAMPLE-SIZE; INFERENCE; SCIENCE; EPIDEMIOLOGY; REPLICATION; DISCLOSURE; KNOWLEDGE; CRITERIA;
D O I
10.1007/s10654-016-0149-3
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Misinterpretation and abuse of statistical tests, confidence intervals, and statistical power have been decried for decades, yet remain rampant. A key problem is that there are no interpretations of these concepts that are at once simple, intuitive, correct, and foolproof. Instead, correct use and interpretation of these statistics requires an attention to detail which seems to tax the patience of working scientists. This high cognitive demand has led to an epidemic of shortcut definitions and interpretations that are simply wrong, sometimes disastrously so-and yet these misinterpretations dominate much of the scientific literature. In light of this problem, we provide definitions and a discussion of basic statistics that are more general and critical than typically found in traditional introductory expositions. Our goal is to provide a resource for instructors, researchers, and consumers of statistics whose knowledge of statistical theory and technique may be limited but who wish to avoid and spot misinterpretations. We emphasize how violation of often unstated analysis protocols (such as selecting analyses for presentation based on the P values they produce) can lead to small P values even if the declared test hypothesis is correct, and can lead to large P values even if that hypothesis is incorrect. We then provide an explanatory list of 25 misinterpretations of P values, confidence intervals, and power. We conclude with guidelines for improving statistical interpretation and reporting.
引用
收藏
页码:337 / 350
页数:14
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