Cefiderocol: A Novel Siderophore Cephalosporin Defeating Carbapenem-resistant Pathogens

被引：37
|
作者：
Bonomo, Robert A. [1 ,2 ,3 ,4 ,5 ,6 ,7 ]
机构：
[1] Vet Affairs Med Ctr, Med Serv, Louis Stokes Cleveland Dept, 10701 East Blvd, Cleveland, OH 44106 USA
[2] Case Western Reserve Univ, Dept Med, Cleveland, OH 44106 USA
[3] Case Western Reserve Univ, Dept Pharmacol, Cleveland, OH 44106 USA
[4] Case Western Reserve Univ, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA
[5] Case Western Reserve Univ, Dept Biochem, Cleveland, OH 44106 USA
[6] Case Western Reserve Univ, Dept Prote & Bioinformat, Cleveland, OH 44106 USA
[7] CWRU Cleveland VAMC Case VA CARES, Cleveland, OH USA
来源：
CLINICAL INFECTIOUS DISEASES | 2019年 / 69卷
关键词：
cefiderocol; cephalosporin; carbapenem-resistant Enterobacteriaceae; nonfermenting gram-negative bacteria; siderophore; GRAM-NEGATIVE PATHOGENS; LACTAMASE INHIBITOR; MULTIDRUG-RESISTANT; BACTERIA;
D O I：
10.1093/cid/ciz823
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Cefiderocol, a novel siderophore cephalosporin in late-stage clinical development, utilizes a "Trojan horse" active transport mechanism to enter bacteria and has proven in vitro activity against carbapenem-resistant gram-negative pathogens, including those with major carbapenem-resistance mechanisms, and stability against all carbapenemases.
引用
收藏
页码：519 / 520
页数：2
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